Biomarkers of exposure and effect in the Brazilian flounder Paralichthys orbignyanus (Teleostei: Paralichthyidae) from the Patos Lagoon estuary (Southern Brazil).
Biomarkers of exposure and effect in the Brazilian flounder Paralichthys orbignyanus (Teleostei: Paralichthyidae) from the Patos Lagoon estuary (Southern Brazil).
复制标题
帕托斯泻湖河口（巴西南部）的巴西牙鲆（Teleostei：Paralichthyidae）的暴露和影响的生物标志物。
DOI：
10.1016/j.marpolbul.2005.11.007
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发表时间：
2006
影响因子：
5.8
通讯作者：
A. Bianchini
中科院分区：
文献类型：
--
作者：
L. Amado;R. Robaldo;L. Geracitano;José María Monserrat;A. Bianchini
在巴西比目鱼Paralichthys orbignyanus从帕托斯泻湖河口（巴西南部）的暴露（肝金属硫蛋白样蛋白含量和过氧化氢酶和谷胱甘肽S-转移酶活性）和污染物的影响（肝脂质过氧化和血细胞DNA损伤）的生物标志物进行了分析。在两个地点收集比目鱼一年：“Coroa do Boi”（污染地点）和“Saco do Justino”（非污染地点）。结果表明，微核细胞频率是区分两个地点比目鱼的最佳生物标志物。两者合计，从DNA损伤分析（微核试验和彗星试验）的数据表明，从非污染网站的比目鱼有效地修复DNA断裂，相反，从污染网站，这可能是他们的DNA修复系统抑制或耗尽。此外，酶活性（过氧化氢酶和GST）和脂质过氧化的数据表明，从污染的网站比目鱼在夏秋两季处于氧化应激。
Biomarkers of exposure (liver metallothionein-like proteins content and catalase and glutathione S-transferase activities) and effect (liver lipoperoxidation and blood cell DNA damage) of contaminants were analyzed in the Brazilian flounder Paralichthys orbignyanus from the Patos Lagoon estuary (Southern Brazil). Flounders were collected for a year in two sites: “Coroa do Boi” (polluted site) and “Saco do Justino” (non-polluted site). Results indicated that micronucleated cells frequency was the best biomarker to distinguish flounders from the two sites. Taken together, data from DNA damage analyses (micronucleus test and comet assay) indicated that flounders from the non-polluted site efficiently repaired the DNA breaks, contrary to those from the polluted site, which probably had their DNA repair system inhibited or exhausted. Furthermore, data from enzyme activities (catalase and GST) and lipid peroxidation indicated that flounders from the polluted site were under oxidative stress in summer and autumn.
影响因子：
2.8
作者：
Tice, RR;Agurell, E;Sasaki, YF
通讯作者：
Sasaki, YF