Time-resolved diffuse optical tomography with patterned-light illumination and detection.
Time-resolved diffuse optical tomography with patterned-light illumination and detection.
复制标题
具有图案光照明和检测的时间分辨分散光学层析成像。
DOI：
10.1364/ol.35.002121
复制
发表时间：
2010-07-01
期刊：
影响因子：
3.6
通讯作者：
Intes X
中科院分区：
文献类型：
--
作者：
Chen J;Venugopal V;Lesage F;Intes X
这项研究探索了基于时间域广场照明和检测策略进行漫反射光学层析成像的可行性。在具有时间门控检测通道的透射率几何中，研究了广场图案化激发和检测方案。采用蒙特卡罗正演模型计算时间分辨雅可比，用于严格的光传输模拟。我们在电子计算机和实验中都证明了基于广域图案光策略的吸收结构重建是可行的，并且在类似数据集大小下优于经典的点激发方案。此外，我们还证明了即使在较大的空间区域被照亮的情况下，时间域信息也保持不变。增强的时间域数据集允许基于与短得多的采集时间相关联的相对较小的数据集在厚组织中进行定量三维成像。
This investigation explores the feasibility of performing diffuse optical tomography based on time-domain wide-field illumination and detection strategies. Wide-field patterned excitation and detection schemes are investigated in transmittance geometry with time-gated detection channels. A Monte Carlo forward model is employed to compute the time-resolved Jacobians for rigorous light propagation modeling. We demonstrate both in silico and experimentally that reconstructions of absorption structures based on wide-field patterned-light strategies are feasible and outperform classical point excitation schemes for similar data set sizes. Moreover, we demonstrate that time-domain information is retained even though large spatial areas are illuminated. The enhanced time-domain data set allows for quantitative three-dimensional imaging in thick tissue based on relatively small data sets associated with much shorter acquisition times.