Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity
Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity
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DOI：
10.1016/s0006-8993(98)00138-3
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发表时间：
1998-05-11
期刊：
影响因子：
2.9
通讯作者：
Akaike, A
中科院分区：
文献类型：
--
作者：
Kihara, T;Shimohama, S;Akaike, A
我们研究了烟碱受体激动剂对β淀粉样蛋白（A β）对大鼠皮层神经元细胞毒性的影响。给予尼古丁可防止A β诱导的神经元死亡。这种神经保护作用可被α 4 β 2烟碱受体拮抗剂二氢-β-erythroidine阻断。此外，与选择性α 4 β 2烟碱受体激动剂金雀花碱孵育，抑制A β细胞毒性。这些结果表明，α 4 β 2烟碱受体活化在神经保护中起着重要作用，对A β细胞毒性。(C)1998年Elsevier Science B.V.
We examined the effects of nicotinic receptor agonists against beta amyloid (A beta) cytotoxicity to rat cortical neurons. Administration of nicotine protected against A beta-induced neuronal death. This neuroprotection was blocked by dihydro-beta-erythroidine, an alpha 4 beta 2 nicotinic receptor antagonist. Furthermore, incubation with cytisine, a selective alpha 4 beta 2 nicotinic receptor agonist, inhibited A beta cytotoxicity. These results suggest that alpha 4 beta 2 nicotinic receptor activation plays an important role in neuroprotection against A beta cytotoxicity. (C) 1998 Elsevier Science B.V.