Cu-Catalyzed Desulfonylative Amination of Benzhydryl Sulfones
Cu-Catalyzed Desulfonylative Amination of Benzhydryl Sulfones
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DOI：
10.1002/chem.201805638
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发表时间：
2019-02-06
影响因子：
4.3
通讯作者：
Crudden, Cathleen M.
中科院分区：
文献类型：
--
作者：
Nambo, Masakazu;Tahara, Yasuyo;Crudden, Cathleen M.
介绍了一种由易得的砜衍生物与胺反应合成苯羟胺的新方法。铜催化的脱磺胺化反应不仅提供了结构多样的苯羟胺，而且还适用于迭代和分子内胺化反应。对照实验表明，生成的铜卡宾中间体来自于砜底物，这代表了一条新的脱磺转化路线。
A new method for the synthesis of benzhydryl amines from the reaction of readily available sulfone derivatives with amines is described. The Cu-catalyzed desulfonylative amination not only provides structurally diverse benzhydryl amines in good yields, but is also applicable to iterative and intramolecular aminations. Control experiments suggested that the formation of a Cu-carbene intermediate generated from the sulfone substrate, which represents a new route for desulfonylative transformations.