Enzymatic Hydrolysis of Cyclopropanes. Total Synthesis of Optically Pure Dictyopterenes A and C
Enzymatic Hydrolysis of Cyclopropanes. Total Synthesis of Optically Pure Dictyopterenes A and C
复制标题
环丙烷的酶水解。
DOI：
10.1002/chin.199122261
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
J. Chuche
中科院分区：
文献类型：
--
作者：
D. Grandjean;P. Pale;J. Chuche
在优化的条件下酶促水解顺式-1，2-二（丁酰氧甲基）环丙烷3，得到定量产率的光学纯顺式-（1 S，2 R）-1-羟甲基-2-丁酰氧甲基环丙烷1。该化合物是一种多用途的环丙烷合成子，如光学纯的海藻信息素Dictyopterenes A和C '的全合成所例示的。
Abstract Enzymatic hydrolysis of cis-1,2-bis(butyryloxymethyl)cyclopropane 3 under optimized conditions gives, in quantitative yield, optically pure cis-(1S,2R)-1-hydroxymethyl-2-butyryloxymethylcyclopropane 1 . This compound is a versatile cyclopropane synthon as exemplified by the total synthesis of optically pure seaweed pheromones Dictyopterenes A and C'.