Cerebral cortex: a topographic segmentation method using magnetic resonance imaging
Cerebral cortex: a topographic segmentation method using magnetic resonance imaging
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DOI：
10.1016/s0925-4927(00)00072-x
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发表时间：
2000-12-04
影响因子：
2.3
通讯作者：
Magnotta, VA
中科院分区：
文献类型：
--
作者：
Crespo-Facorro, B;Kim, JJ;Magnotta, VA
磁共振成像（MRI）技术的显著发展为探索人类大脑皮层的体内形态特征提供了广泛的潜在应用。基于磁共振成像的大脑皮层分割方法可以阐明反映脑部疾病潜在神经病理过程的特定脑亚区结构异常。本研究详细描述了将大脑皮层划分为41个亚区的指导方针。我们的方法保留了个体大脑的地形独特性，并基于我们同时可视化三个正交平面、三角化灰质等值面和三维渲染大脑的能力。基于单个沟的地形标志，将每个子区域手工分割成一组连续的冠状或横轴切片。可靠性研究表明，大脑皮层可以可靠地包裹；各子区域的类内相关系数为0.60 ~ 0.99。该方法的有效性得到了这样一个事实的支持，即脑回细分与我们中心进行的功能成像研究所描绘的区域相似。最终，这种方法将允许我们检测细微的形态损伤或在限定的皮层亚区发现功能激活的异常模式。对区域结构和功能皮层异常的全面描述将进一步深入了解不同亚区在脑疾病病理生理学中的作用。(C) 2000爱思唯尔科学爱尔兰有限公司版权所有。
Remarkable developments in magnetic resonance imaging (MRI) technology provide a broad range of potential applications to explore in vivo morphological characteristics of the human cerebral cortex. MR-based parcellation methods of the cerebral cortex may clarify the structural anomalies in specific brain subregions that reflect underlying neuropathological processes in brain illnesses. The present study describes detailed,guidelines for the parcellation of the cerebral cortex into 41 subregions. Our method conserves the topographic uniqueness of individual brains and is based on our ability to visualize the three orthogonal planes, the triangulated gray matter isosurface and the three-dimensional (3D) rendered brain simultaneously. Based upon topographic landmarks of individual sulci, every subregion was manually segmented on a set of serial coronal or transaxial slices consecutively. The reliability study indicated that the cerebral cortex could be parcelled reliably; intraclass correlation coefficients for each subregion ranged from 0.60 to 0.99. The validity of the method is supported by the fact that gyral subdivisions are similar to regions delineated in functional imaging studies conducted in our center. Ultimately, this method will permit us to detect subtle morphometric impairments or to find abnormal patterns of functional activation in circumscribed cortical subregions. The description of a thorough map of regional structural and functional cortical abnormalities will provide further insight into the role that different subregions play in the pathophysiology of brain illnesses. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.