Categories of placebo response in the absence of site-specific expectation of analgesia
Categories of placebo response in the absence of site-specific expectation of analgesia
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DOI：
10.1016/j.pain.2006.06.021
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发表时间：
2006-12-15
期刊：
影响因子：
7.4
通讯作者：
Jones, A. K. P.
中科院分区：
文献类型：
--
作者：
Watson, A.;El-Deredy, W.;Jones, A. K. P.
实验性安慰剂镇痛是通过建立减少特定身体部位疼痛的预期来诱导的，通常使用以局部麻醉为幌子的惰性乳膏并结合调理。我们通过让受试者期望一只手臂上有麻醉药膏来研究非部位特异性安慰剂镇痛，但没有具体说明他们是否一定会接受麻醉药膏，或者可能会应用于哪只手臂。来自 CO2 激光的疼痛热脉冲（150 毫秒）被随机传送到双臂。治疗组（n = 24）接受三个实验组（乳霜前、乳霜后调理和调理后）。在调节块期间，仅降低一只手臂的刺激强度。在后调节块中，它恢复到疼痛水平。我们评估了与预奶油块相比后调理后强度等级的变化。与对照组 (n = 16) 相比，治疗组报告强度等级显着降低 (F-1、F-38 = 12.1；p = 0.001)。在治疗组中，我们观察到一系列安慰剂反应：单侧反应者（33.3%）、仅在条件组中出现安慰剂反应的受试者；双侧反应者（33.3%）、报告双臂强度等级降低的受试者以及无反应者，其强度等级不受条件反射的影响。我们根据不同水平的预期镇痛来讨论这些反应……由于缺乏特定部位的治疗焦点而促进了这些反应。我们认为，这使得个体的暗示性能够通过将不同水平的期望与来自实际疼痛刺激的信息相结合来影响他们对疼痛体验的评估。 (c) 2006 年国际疼痛研究协会。由 Elsevier B.V. 出版。保留所有权利。
Experimental placebo analgesia is induced by building an expectation of reduced pain in a specific body part, usually using an inert cream in the guise of a local anaesthetic in conjunction with conditioning. We investigated non-site-specific placebo analgesia by conditioning subjects to expect the anaesthetic cream on one arm, without specifying if they will definitely receive the cream, or to which arm it might be applied. Painful heat pulses (150 ms) from a CO2 laser were delivered randomly to both arms. A treatment group (n = 24) underwent three experimental blocks (pre-cream, conditioning after cream, and post-conditioning). During the conditioning block, the intensity of the stimulus was reduced on one arm only. In the post-conditioning block it was returned to the painful level. We evaluated the change of intensity rating post-conditioning compared to the pre-cream block. In contrast to a control group (n = 16), the treatment group reported a significant reduction in intensity ratings (F-1,F-38 = 12.1; p = 0.001). In the treatment group, we observed a range of placebo responses: unilateral responders (33.3%), subjects with a placebo response in the conditioned arm only; bilateral responders (33.3%), subjects reporting reduction in the intensity ratings in both arms, and non-responders, whose intensity ratings were not influenced by conditioning. We discuss these responses in terms of different levels of expected analgesia.. facilitated by the absence of a site-specific focus for the treatment. We suggest this allowed the individuals suggestibility to influence their assessment of the pain experience by combining different levels of expectation with the information from the actual pain stimulus. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.