Androgen-Induced Immunosuppression.
Androgen-Induced Immunosuppression.
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DOI：
10.3389/fimmu.2018.00794
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发表时间：
2018
影响因子：
7.3
通讯作者：
Jorgensen TN
中科院分区：
文献类型：
--
作者：
Gubbels Bupp MR;Jorgensen TN
除了决定生物性别外，性激素还可以通过调节免疫细胞活动和调节靶器官对免疫介导的损伤的易感性来影响健康和疾病。全身性自身免疫性疾病，如系统性红斑狼疮、类风湿性关节炎和多发性硬化症在女性中更为普遍，而癌症则表现出相反的模式。性激素被反复暗示在这些偏见中发挥作用。在这篇综述中，我们将讨论雄激素和功能性雄激素受体的表达如何影响免疫细胞，以及这如何抑制或改变免疫反应，影响自身免疫性疾病的发病率和进展。
In addition to determining biological sex, sex hormones are known to influence health and disease via regulation of immune cell activities and modulation of target-organ susceptibility to immune-mediated damage. Systemic autoimmune disorders, such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis are more prevalent in females, while cancer shows the opposite pattern. Sex hormones have been repeatedly suggested to play a part in these biases. In this review, we will discuss how androgens and the expression of functional androgen receptor affect immune cells and how this may dampen or alter immune response(s) and affect autoimmune disease incidences and progression.