Altered regional blood volume in chronic cannabis smokers.
Altered regional blood volume in chronic cannabis smokers.
复制标题
改变长期吸食大麻者的局部血容量。
DOI：
10.1037/1064-1297.14.4.422
复制
发表时间：
2006
影响因子：
2.3
通讯作者：
Yurgelun-Todd,DeborahA
中科院分区：
文献类型：
--
作者：
Sneider,JenniferT;PopeJr,HarrisonG;Silveri,MarisaM;Simpson,NorahS;Gruber,StaciA;Yurgelun-Todd,DeborahA
脑灌注的定量测量对于研究正常和受损的人脑功能至关重要。虽然大麻是美国最常滥用的非法物质，但其对脑血容量的影响尚未得到充分研究。本研究的目的是检查在一段时间内的监督禁欲大麻的利益-包括额叶，颞叶和小脑的局灶性区域的相对区域血容量的差异。动态磁敏感对比MRI数据收集了12个当前，长期每日大麻用户之间的6和36小时后，受试者的最后一次报告使用大麻。在17名健康对照受试者中也采集了静息状态CBV图像。使用1.5特斯拉GE Signa扫描仪在钆对比剂推注后在轴向平面采集数据。大麻使用者表现出显着增加的血容量在右额区（p<. 05），左颞区（p<. 005），小脑（p<. 005)相对于比较对象。在大麻使用者中，区域血容量与吸烟或尿四氢大麻酚浓度的总终生发作之间没有显着相关性。这些发现对于理解长期大量使用大麻对大脑功能的影响具有重要意义。将研究扩展到大麻戒断6-36小时以上，以确定CBV值增加是否持续数周或最终恢复正常，这将是有意义的。（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
The quantitative measurement of cerebral perfusion is crucial for the study of both normal and impaired human brain function. Although cannabis is the most commonly abused illicit substance in the United States, its effects on cerebral blood volume (CBV) have not been fully examined. The objective of the present study was to examine differences in relative regional blood volume in focal regions of interest--including the frontal lobe, the temporal lobe, and the cerebellum--during a period of supervised abstinence from cannabis. Dynamic susceptibility contrast MRI data were collected on 12 current, long-term daily cannabis users between 6 and 36 hr after the subjects' last reported cannabis use. Resting-state CBV images were also acquired in 17 healthy comparison subjects. Data were acquired in the axial plane with a 1.5-Tesla GE Signa scanner following a bolus of gadolinium contrast agent. Cannabis users demonstrated significantly increased blood volumes in the right frontal area (p<. 05), in the left temporal area (p<. 005), and in the cerebellum (p<. 005) relative to comparison subjects. Among the cannabis users, there were no significant correlations between regional blood volumes and either total lifetime episodes of smoking or urinary tetrahydrocannabinol concentrations. These findings have important implications for understanding the effects of chronic heavy cannabis use on brain function. It would be of interest to extend the investigation beyond 6-36 hr of abstinence from cannabis to determine whether increased CBV values persist for several weeks or eventually normalize.(PsycINFO Database Record (c) 2016 APA, all rights reserved)