Modified DNA analogues that sense light exposure with color changes
Modified DNA analogues that sense light exposure with color changes
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DOI：
10.1021/ja046910o
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发表时间：
2004-10-13
影响因子：
15
通讯作者：
Kool, ET
中科院分区：
文献类型：
--
作者：
Gao, JM;Watanabe, S;Kool, ET
我们报道了一类新的光敏分子的发现。这些光传感器由组装在DNA骨架上的荧光团低聚物组成。合成了由超过14000种化合物组成的四荧光团组合库，并筛选了对光暴露的快速反应。在最光敏的分子中，至少有三种四聚体被发现对光照有明显的颜色变化，而不是简单的光漂白。
We report the discovery of a new class of light-sensing molecules. These light sensors are composed of fluorophore oligomers assembled on a DNA backbone. A combinatorial library of tetrafluorophores consisting of over 14 000 compounds was synthesized and screened for rapid responses toward light exposure. Among the most light-sensitive molecules, at least three tetramers were found to respond to light exposure with apparent color changes, rather than simple photobleaching.