Fine-tuning CD4+ central memory T cell heterogeneity by strength of stimulation
Fine-tuning CD4+ central memory T cell heterogeneity by strength of stimulation
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DOI：
10.1002/eji.200738044
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发表时间：
2008-01-01
影响因子：
5.4
通讯作者：
Ahmed, Rafi
中科院分区：
文献类型：
--
作者：
Kalia, Vandana;Sarkar, Surojit;Ahmed, Rafi
记忆T细胞池是一个相对长寿的异质的抗原经验T细胞的储存库，这些T细胞“记住”以前与抗原的接触。虽然记忆T细胞池中的异质性现在已经被很好地建立，但调节这种记忆T细胞异质性的产生的信号还没有完全被理解。本期《欧洲免疫学杂志》上的两篇文章强调了抗原刺激的强度在调节表型和功能不同的CD4(+)T细胞记忆亚群的产生方面的重要性。还提供了对关键分子的新见解，这些分子可能调节记忆亚集之间的自稳和二次扩展的差异。
The memory T cell pool serves as a relatively long-lived heterogeneous repository of antigen-experienced T cells that "remember" previous encounters with antigen. While heterogeneity in the memory T cell pool is now well established, signals regulating the generation of this memory T cell heterogeneity are not fully understood. Two articles in this issue of the European Journal of Immunology highlight the importance of the strength of antigenic stimulation in regulating the generation of phenotypically and functionally distinct CD4(+) T cell memory subsets. New insights are also provided into key molecular players that likely mediate differences in homeostatic and secondary expansion between the memory subsets.