THE PATHOLOGICAL BASIS AND MICRO-ANATOMY OF OCCLUSIVE THROMBUS FORMATION IN HUMAN CORONARY-ARTERIES
THE PATHOLOGICAL BASIS AND MICRO-ANATOMY OF OCCLUSIVE THROMBUS FORMATION IN HUMAN CORONARY-ARTERIES
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DOI：
10.1098/rstb.1981.0101
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发表时间：
1981-01-01
影响因子：
6.3
通讯作者：
THOMAS, T
中科院分区：
文献类型：
--
作者：
DAVIES, MJ;THOMAS, T
心肌坏死，通常称为梗死，发生在不同的模式。常见的形式是左心室的1个节段坏死，即，前部、间隔部、侧部或后部。这种区域性梗死与供血动脉的急性闭塞性血栓形成有关。弥漫性坏死累及整个脑室周围，通常是脑室内膜下区，并不总是与血栓有关。从间隔150 μ m的连续切片中完整重建了死后冠状动脉造影中识别的阻塞性血栓。大多数闭塞性血栓与动脉粥样硬化斑块处进入内膜的夹层有关。斑块的破裂通常延伸几毫米，通常呈螺旋状，因此斑块内的血栓块压缩了原始管腔。先前关于斑块破裂或破裂的报道大大低估了血液进入内膜的程度。
Myocardial necrosis, usually called infarction, occurs in different patterns. A common form is necrosis of 1 segment of the left ventricle, i.e., anterior, septal, lateral or posterior. This regional infarction is consistently associated with an acute occlusive thrombosis of the artery supplying that region. Diffuse necrosis involving the whole circumference, usually the subendocardial zone, of the ventricle is not consistently associated with thrombi. Occlusive thrombi identified in post-mortem coronary arteriograms were reconstructed in their entirety from serial sections at 150-.mu.m intervals. Most occlusive thrombi were associated with a dissection track into the intima at an atheromatous plaque. The break into the plaque usually extended over several millimeters, often in spirals, so that a mass of thrombus within the plaque compressed the original lumen. Previous accounts of plaque rupture or cracking greatly underestimated the magnitude of the dissection of blood into the intima.