Sugar and pH dual-responsive mesoporous silica nanocontainers based on competitive binding mechanisms.
Sugar and pH dual-responsive mesoporous silica nanocontainers based on competitive binding mechanisms.
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DOI：
10.1039/c4nr04796f
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发表时间：
2015-01
期刊：
影响因子：
6.7
通讯作者：
M. D. Yilmaz;Min Xue;M. Ambrogio;Onur Buyukcakir;Yilei Wu;M. Frasconi;Xinqing Chen;M. Nassar;J. Stoddart;J. Zink
中科院分区：
文献类型：
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作者：
M. D. Yilmaz;Min Xue;M. Ambrogio;Onur Buyukcakir;Yilei Wu;M. Frasconi;Xinqing Chen;M. Nassar;J. Stoddart;J. Zink
基于邻苯二酚和硼酸在介孔二氧化硅纳米粒子（MSNs）平台上的结合，开发了一种糖和pH双重响应的控释系统，该系统对分子刺激物具有高度特异性。通过将苯基硼酸茎接枝到二氧化硅表面上，含儿茶酚的β-环糊精可以通过形成硼酸酯而连接到MSN的纳米孔的孔上，所述硼酸酯阻止进入纳米孔。这些酯足够稳定，可以防止货物分子逃逸。硼酸酯在糖的存在下解离，从而实现该混合系统的分子特异性控释特征。已发现释放速率可通过改变糖的结构和浓度来调节，这是由于与其操作机制相关的竞争性结合性质。酸化还诱导货物分子的释放。进一步的研究表明，低pH和糖分子的存在提供了共同控制释放速率的协同效应。
A sugar and pH dual-responsive controlled release system, which is highly specific towards molecular stimuli, has been developed based on the binding between catechol and boronic acid on a platform of mesoporous silica nanoparticles (MSNs). By grafting phenylboronic acid stalks onto the silica surface, catechol-containing β-cyclodextrins can be attached to the orifices of the MSNs' nanopores through formation of boronate esters which block access to the nanopores. These esters are stable enough to prevent cargo molecules from escaping. The boronate esters disassociate in the presence of sugars, enabling the molecule-specific controlled-release feature of this hybrid system. The rate of release has been found to be tunable by varying both the structures and the concentrations of sugars, as a result of the competitive binding nature associated with the mechanism of its operation. Acidification also induces the release of cargo molecules. Further investigations show that the presence of both a low pH and sugar molecules provides cooperative effects which together control the rate of release.