Serial Intervals and the Temporal Distribution of Secondary Infections within Households of 2009 Pandemic Influenza A (H1N1): Implications for Influenza Control Recommendations
Serial Intervals and the Temporal Distribution of Secondary Infections within Households of 2009 Pandemic Influenza A (H1N1): Implications for Influenza Control Recommendations
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DOI：
10.1093/cid/ciq028
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发表时间：
2011-01-01
影响因子：
11.8
通讯作者：
Ferguson, Neil M.
中科院分区：
文献类型：
--
作者：
Donnelly, Christl A.;Finelli, Lyn;Ferguson, Neil M.
2009年甲型H1N1流感大流行期间的一个关键问题是确定流感样疾病(ILI)患者应保持隔离的适当时间，以减少继续传播，同时限制社会破坏。理想情况下，这是基于对感染过程中每个时间点患病个体的相对传染性的了解。对2009年初在美国进行的7项流行病学研究中的261对临床表现为甲型H1N1流感的家庭感染者-感染者对的数据进行了分析，以估计从感染者出现症状到他们感染的家庭接触者出现症状的时间分布(平均为2.9天，不考虑三次传播)。在感染PH1N1病毒的患者中，估计只有5%的传播事件发生在临床症状出现3天后。这些结果将为未来关于ILI患者隔离时间的建议提供信息。
A critical issue during the 2009 influenza A (H1N1) pandemic was determining the appropriate duration of time individuals with influenza-like illness (ILI) should remain isolated to reduce onward transmission while limiting societal disruption. Ideally this is based on knowledge of the relative infectiousness of ill individuals at each point during the course of the infection. Data on 261 clinically apparent pH1N1 infector-infectee pairs in households, from 7 epidemiological studies conducted in the United States early in 2009, were analyzed to estimate the distribution of times from symptom onset in an infector to symptom onset in the household contacts they infect (mean, 2.9 days, not correcting for tertiary transmission). Only 5% of transmission events were estimated to take place > 3 days after the onset of clinical symptoms among those ill with pH1N1 virus. These results will inform future recommendations on duration of isolation of individuals with ILI.