Estrogen-TGFβ cross-talk in bone and other cell types:: Role of TIEG, Runx2, and other transcription factors
Estrogen-TGFβ cross-talk in bone and other cell types:: Role of TIEG, Runx2, and other transcription factors
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DOI：
10.1002/jcb.21425
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发表时间：
2008-02-01
影响因子：
4
通讯作者：
Spelsberg, T. C.
中科院分区：
文献类型：
--
作者：
Hawse, J. R.;Subramaniam, M.;Spelsberg, T. C.
众所周知，E-2和转化生长因子β在包括骨在内的多种组织中具有重要的生物学效应。这两个因素导致其影响的信号通路已经得到了很好的证明。然而，这两条通路之间的相互作用以及E2和转化生长因子β之间的相互作用的潜在后果仍在被阐明。在这份招股说明书中，我们介绍了TIEG、Runx2和其他转录因子作为这两条通路之间重要信号媒介的已知和潜在作用。
It is well established that E-2 and TGF beta have major biological effects in multiple tissues, including bone. The signaling pathways through which these two factors elicit their effects are well documented. However, the interaction between these two pathways and the potential consequences of cross-talk between E2 and TGF beta continue to be elucidated. In this prospectus, we present known and potential roles of TIEG, Runx2, and other transcription factors as important mediators of signaling between these two pathways.