Evaluation of the association between urinary cadmium levels below threshold limits and the risk of diabetes mellitus: a dose-response meta-analysis
Evaluation of the association between urinary cadmium levels below threshold limits and the risk of diabetes mellitus: a dose-response meta-analysis
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尿镉水平低于阈值与糖尿病风险之间关系的评估：剂量反应荟萃分析
DOI：
10.1007/s11356-019-04943-3
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发表时间：
2019-07-01
影响因子：
5.8
通讯作者：
Zhang, Zeng-Li
中科院分区：
文献类型：
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作者：
Guo, Fei-Fei;Hu, Zhi-Yong;Zhang, Zeng-Li
随着环境中镉含量的增加，与慢性病相关的镉暴露的不利影响正受到越来越多的关注。关于镉和糖尿病(DM)之间的关系，已经进行了几项基于人群的研究，但报道了有争议的结果。在这里，我们的目的是评估镉暴露与糖尿病之间的关系。在这项荟萃分析中，使用了随机效应模型，因为有证据表明研究之间存在异质性。剂量-效应关系通过三结点的三次受限三次样条法模型进行评估。结果表明，体内镉水平与糖尿病呈正相关(OR=1.27；95%CI，1.07~1.52)。体内镉水平是根据尿镉和血镉的组合来定义的。亚组分析进一步显示尿镉水平与糖尿病呈正相关(OR=1.31；95%CI，1.02~1.69)。剂量-反应分析结果显示，尿镉水平高于2.43g/g肌酐与糖尿病呈正相关，尿镉水平每增加1g/g，患糖尿病风险增加16%。我们的荟萃分析结果表明，体内镉水平与糖尿病呈正相关，尿镉水平高于2.43g/g肌酐与糖尿病风险增加相关。
As cadmium levels are increasing in the environment, the adverse effects of cadmium exposure specifically associated with chronic diseases are receiving increasing attention. Several population-based studies have been conducted on the association between cadmium and diabetes mellitus (DM) but have reported controversial results. Here, we aimed to evaluate the association between cadmium exposure and DM. In this meta-analysis, a random effects model was used because there was evidence of heterogeneity among studies. A dose-response relationship was assessed through a restricted cubic spline model with three knots. The results showed a positive association between cadmium levels in the body and DM (OR=1.27; 95% CI, 1.07-1.52). The cadmium levels in the body were defined on the basis of combined urinary and blood cadmium. Subgroup analysis further indicated a positive association between urinary cadmium levels and DM (OR=1.31; 95% CI, 1.02-1.69). The dose-response analysis results showed a positive association between levels of urinary cadmium above 2.43g/g creatinine and DM, and the risk of DM increased by 16% for each lg/g creatinine increase in urinary cadmium levels. The results from our meta-analysis indicate that cadmium levels in the body are positively associated with DM, and urinary cadmium levels above 2.43g/g creatinine are associated with an increased risk of DM.