Autoimmune pancreatitis-associated prostatitis: Distinct clinicopathological entity
Autoimmune pancreatitis-associated prostatitis: Distinct clinicopathological entity
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DOI：
10.1111/j.1440-1827.2007.02199.x
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发表时间：
2008-02-01
影响因子：
2.2
通讯作者：
Ota, Hiroyoshi
中科院分区：
文献类型：
--
作者：
Uehara, Takeshi;Hamano, Hideaki;Ota, Hiroyoshi
自身免疫性胰腺炎（Autoimmune pancreatitis，AIP）是近年来提出的一种以血清IgG 4水平升高为特征性表现的疾病，有时与其他炎症性疾病如腹膜后纤维化和硬化性胆管炎相关。为探讨AIP相关性前列腺炎（AIP-P）的临床病理特征，对AIP-P患者的临床病理特征进行了分析，并对AIP-P患者血清IgG亚类的表达进行了免疫组化检测。（IgG1，IgG2，IgG3，和IgG 4）在六个AIP-P组与10例临床诊断为可疑癌但组织学检查有局灶性炎症而无腺癌的对照组比较检查前列腺。所有AIP-P患者均具有AIP的特征性表现，激素治疗后下尿路症状（LUTS）改善。在5例AIP-P患者中，4例直肠指检提示前列腺肿大。组织学上，AIP-P有淋巴浆细胞和散在嗜酸性粒细胞浸润和闭塞性静脉炎，伴腺体萎缩和致密纤维化。免疫组化结果显示，AIP-P组的IgG 4阳性浆细胞/单核细胞比率显著高于对照组（P = 0.0011）。AIP-P是一种独特的临床病理实体，其机制可能与AIP的机制相似。
Autoimmune pancreatitis (AIP) has been recently proposed as a disease entity, and an elevated serum IgG4 level is a characteristic finding in it. This disease is sometimes associated with other inflammatory diseases, such as retroperitoneal fibrosis and sclerosing cholangitis. To elucidate the clinicopathological characteristics of AIP-associated prostatitis (AIP-P), the clinicopathological findings of AIP-P patients were evaluated, and the immunohistochemical expression of the IgG subclasses (IgG1, IgG2, IgG3, and IgG4) in six AIP-P patients was compared with that in 10 control patients who were clinically diagnosed as suspicious for carcinoma but who had focal inflammation without adenocarcinoma on histological examination of the prostate. All AIP-P patients had the characteristic findings of AIP, and their lower urinary tract symptoms (LUTS) improved after steroid therapy. In four of five AIP-P patients, digital rectal examination indicated prostate enlargement. Histologically, AIP-P had lymphoplasmacytic and scattered eosinophilic infiltration and obliterative phlebitis accompanying gland atrophy with dense fibrosis. Immunohistochemically, the IgG4-positive plasma cell/mononuclear cell ratio was significantly higher in the AIP-P group than in the control group (P = 0.0011). AIP-P is a distinct clinicopathological entity, and a mechanism similar to that implicated in AIP may be involved in it as well.