Interactive effects of 5-HTTLPR genotype and rearing environment on affective attitude towards own infant in Japanese mothers.
Interactive effects of 5-HTTLPR genotype and rearing environment on affective attitude towards own infant in Japanese mothers.
复制标题
5-HTTLPR 基因型和养育环境对日本母亲对自己婴儿的情感态度的交互影响。
DOI：
10.1016/j.bbr.2016.11.001
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发表时间：
2017
影响因子：
2.7
通讯作者：
K.
中科院分区：
文献类型：
--
作者：
Sawano;E.;Doi;H.(equally contributing);Nagai;T.;Ikeda;S.;Shinohara;K.
母亲对自己婴儿的积极态度是有效育儿的基石。以往的研究揭示了遗传和环境因素对母亲养育行为的影响，但很少有人知道潜在的基因-环境相互作用在塑造母亲的情感态度。为了解决这个问题，我们调查了母亲的童年养育环境和5-羟色胺转运体基因多态性（5-HTTLPR）对婴儿的情感态度的影响。我们的分析发现，养育环境和5-HTTLPR基因型之间的交互作用对母亲的态度。具体而言，一个不良的养育环境（特点是低产妇照顾和高父亲的过度保护）减少了积极的态度，对自己的婴儿在母亲与纯合子短等位基因型。相比之下，这种不利影响在长等位基因携带者中几乎被消除。总之，我们的研究结果表明，5-HTTLPR基因温和的影响，经验丰富的养育环境对母亲的父母行为的方式一致的概念，即短5-HTTLPR等位基因放大环境的影响。
Maternal positive attitude towards one’s own infant is the cornerstone of effective parenting. Previous research has revealed an influence of both genetic and environmental factors on maternal parenting behavior, but little is known of the potential gene-environment interaction in shaping a mother’s affective attitude. To address this gap, we investigated the effect of a mother’s childhood rearing environment and a serotonin transporter gene polymorphism (5-HTTLPR) on affective attitude towards her infant.Our analyses found an interactive effect between rearing environment and 5-HTTLPR genotype on maternal attitude. Specifically, a poor rearing environment (characterized by low maternal care and high paternal overprotection) decreased positive attitude towards one’s own infant in mothers with homozygous short allele genotype. In contrast, this detrimental effect was almost eliminated in long allele carriers. Altogether, our results indicate that the 5-HTTLPR gene moderates the influence of experienced rearing environment on maternal parental behavior in a manner consistent with the notion that the short 5-HTTLPR allele amplifies environmental influence.