Correlates of high HDL cholesterol among women with coronary heart disease
Correlates of high HDL cholesterol among women with coronary heart disease
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DOI：
10.1016/s0002-8703(00)90238-2
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发表时间：
2000-02-01
影响因子：
4.8
通讯作者：
Stefanick, ML
中科院分区：
文献类型：
--
作者：
Bittner, V;Simon, JA;Stefanick, ML
背景国家胆固醇教育计划(NCEP)已将高密度脂蛋白胆固醇(HDLC)大于或等于60 mg/dl列为冠心病(CHD)的危险因素，但相当大比例的冠状动脉事件发生在女性中，尽管高密度脂蛋白胆固醇(HDLC)水平较高。方法与结果本研究的目的是对绝经后女性高密度脂蛋白胆固醇(HDLC)大于或等于60 mg/dl的高发CHD进行特征分析，并找出可能减弱高HDLC保护作用的因素。我们分析了2763名绝经后妇女雌激素/孕激素替代疗法的随机双盲研究的基线数据。
Background The National Cholesterol Education Program (NCEP) has designated high-density lipoprotein cholesterol (HDLC) greater than or equal to 60 mg/dl a "negative" coronary heart disease (CHD) risk factor, but a substantial proportion of coronary events occur among women despite high HDL-C levels.Methods and Results The objective of this study was to characterize postmenopausal women with prevalent CHD despite HDL-C greater than or equal to 60 mg/dl and to identify factors that may attenuate the protective effect of high HDL-C. We analyzed baseline data from a randomized, double-blind study of estrogen/progestin replacement therapy in 2763 postmenopausal women