Inflammatory and Insulinemic Dietary Patterns: Influence on Circulating Biomarkers and Prostate Cancer Risk.
Inflammatory and Insulinemic Dietary Patterns: Influence on Circulating Biomarkers and Prostate Cancer Risk.
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DOI：
10.1158/1940-6207.capr-20-0236
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Tabung FK
中科院分区：
文献类型：
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作者：
Aroke D;Folefac E;Shi N;Jin Q;Clinton SK;Tabung FK
前列腺癌(PCA)在饮食结构富裕的国家很常见，代表着具有不同行为的不同亚型的集合。专注于个别营养素或食物的简化论策略并没有明确定义风险因素。我们已经开发了基于机制的饮食模式，专注于炎症和慢性胰岛素高分泌；这些过程被假设为影响前列腺癌的发生。在前列腺癌、肺癌、结直肠癌和卵巢癌队列中，我们从3517名在登记时提供血液样本的男性和女性的食物频率问卷数据中计算了高胰岛素血症的经验饮食指数(EDIH)和经验饮食炎症模式(EDIP)得分。我们在多变量调整的线性回归中使用这些分数来验证EDIH和EDIP与相关循环生物标记物的相关性。在49,317名男性的单独样本中，我们使用多变量调整的COX回归来评估EDIH和EDIP与PCa(总风险和亚型风险)的相关性。摄入高胰岛素饮食(EDIH五分位数为5)的受试者C-肽、胰岛素、C反应蛋白、肿瘤坏死因子α-R2浓度显著高于五分位数饮食的受试者，而脂联素水平低于五分位数饮食的受试者。类似地，食用最易发炎饮食的受试者的IL-6、肿瘤坏死因子α-R2、C-肽、胰岛素浓度显著高于五分位数饮食的受试者，而脂联素水平较低。食用高胰岛素饮食的男性总体PCa风险较高：HRquintile5vs1，1.11；95%CI，1.01，1.23；P趋势=0.03，尤其是高级别癌症：HRquintile5vs1，1.18；95%CI，1.02，1.37；P趋势=0.06；EDIP与PCa风险无关。总之，EDIH和EDIP预测了已知的胰岛素和炎症生物标志物的浓度，EDIH进一步预测了未来PCa的风险。减少高胰岛素饮食的不良作用的干预措施可能是预防前列腺癌的一种手段。
Prostate cancer (PCa) is common in countries with affluent dietary patterns and represents a heterogeneous collection of subtypes with varying behavior. Reductionist strategies focusing on individual nutrients or foods have not clearly defined risk factors. We have developed mechanisms-based dietary patterns focusing upon inflammation and chronic insulin hypersecretion; processes that are hypothesized to impact prostate carcinogenesis. In the Prostate Lung Colorectal &Ovarian cancer cohort, we calculated the empirical dietary index for hyperinsulinemia (EDIH) and empirical dietary inflammatory pattern (EDIP) scores from food frequency questionnaire data among 3,517 men and women who provided a blood sample at enrollment. We used these scores in multivariable-adjusted linear regression to validate EDIH and EDIP against relevant circulating biomarkers. In a separate sample of 49,317 men, we used multivariable-adjusted Cox regression to evaluate associations of EDIH and EDIP with PCa (total and subtypes) risk. Participants consuming the most hyperinsulinemic diets (EDIH quintile 5) had significantly higher concentrations of C-peptide, insulin, CRP, TNFα-R2 and lower adiponectin, than those in quintile 1. Similarly, participants consuming the most pro-inflammatory diets had significantly higher concentrations of IL-6, TNFα-R2, C-peptide, insulin and lower adiponectin. Men consuming hyperinsulinemic diets were at higher total PCa risk: HRquintile5vs1, 1.11;95%CI, 1.01, 1.23;P-trend=0.03, especially high-grade cancer: HRquintile5vs1, 1.18;95%CI, 1.02, 1.37;P-trend=0.06; The EDIP was not associated with PCa risk. In summary, EDIH and EDIP predicted concentrations of known insulinemic and inflammatory biomarkers and EDIH further predicted risk of future PCa. Interventions to reduce the adverse role of hyperinsulinemic diets may be a means of PCa prevention.