Energetics of active fluctuations in living cells
Energetics of active fluctuations in living cells
复制标题
活细胞主动波动的能量学
DOI：
10.1103/physreve.90.042724
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发表时间：
2014
影响因子：
2.4
通讯作者：
F. van Wijland
中科院分区：
文献类型：
--
作者：
E. Fodor;K. Kanazawa;H. Hayakawa;P. Visco;F. van Wijland
在活细胞中发生的非平衡活动可以通过嵌入在介质中的示踪剂进行监测。虽然基于这种探针的光学操纵的微观流变学实验已经变得越来越标准，但我们提出了一些具有替代方案的实验，我们声称，这些实验将提供对活跃波动的能量学的洞察。这是基于要么在控制参数空间中执行类似热力学的循环，要么在简单的平移之外确定对封闭陷阱的外部扰动的响应。我们阐述了我们关于主动巡回布朗振子的建议，该振子模拟了嵌入在生物介质中的探测器的动力学。
The nonequilibrium activity taking place in a living cell can be monitored with a tracer embedded in the medium. While microrheology experiments based on optical manipulation of such probes have become increasingly standard, we put forward a number of experiments with alternative protocols that, we claim, will provide insight into the energetics of active fluctuations. These are based on either performing thermodynamiclike cycles in control-parameter space or determining response to external perturbations of the confining trap beyond simple translation. We illustrate our proposals on an active itinerant Brownian oscillator modeling the dynamics of a probe embedded in a living medium.