Beneficial effects of monounsaturated fatty acid‐rich blended oils with an appropriate polyunsaturated/saturated fatty acid ratio and a low n‐6/n‐3 fatty acid ratio on the health of rats
Beneficial effects of monounsaturated fatty acid‐rich blended oils with an appropriate polyunsaturated/saturated fatty acid ratio and a low n‐6/n‐3 fatty acid ratio on the health of rats
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富含单不饱和脂肪酸、适当的多不饱和/饱和脂肪酸比例和低n-6/n-3脂肪酸比例的混合油对大鼠健康的有益作用
DOI：
10.1002/jsfa.12083
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发表时间：
2022
影响因子：
4.1
通讯作者：
Guiju Sun
中科院分区：
文献类型：
--
作者：
Ligang Yang;Chao Yang;Chu Chu;Min Wan;Dengfeng Xu;Da Pan;Hui Xia;Shaokang Wang;Guofang Shu;Shiqing Chen;Guiju Sun
膳食脂肪对健康的影响受其脂肪酸组成的影响。我们的目的是确定富含单不饱和脂肪酸（MUFA）的混合油（BO）的多不饱和脂肪酸（PUFA）和饱和脂肪酸（SFA）的平衡和低n-6/n-3 PUFA比例对正常或高脂肪饮食大鼠健康的影响。BO由红棕榈油、米糠油（RO）、茶籽油和亚麻籽油按适当比例混合而成，食用BO可降低血清低密度脂蛋白胆固醇（LDL-C）、非酯化脂肪酸（NEFA）、胰岛素（INS）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1（IL-1）、高敏C反应蛋白（hs-CRP）、丙二醛（MDA）、脂质过氧化物（LPO）和氧化低密度脂蛋白（ox-LDL）浓度以及胰岛素抵抗的稳态模型评估（HOMA-IR）;与对照含油正常和高脂饮食相比，其增加高密度脂蛋白胆固醇（HDL-C）、谷胱甘肽过氧化物酶（GSH-Px）和超氧化物歧化酶（SOD）浓度以及骨矿物质密度（BMD）。BO还降低了甘油三酯（TG），hs-CRP，MDA，ox-LDL和活性氧（ROS）浓度，并增加血清HDL-C和SOD，BMD与含RO的高脂饮食。最后，BO降低了葡萄糖（GLU）和INS，HOMA-IR;与含RO的正常饮食相比，它增加了HDL-C，SOD，股骨重量和BMD。具有适当脂肪酸谱的BO在正常和高脂饮食中对大鼠的糖脂代谢，炎症，氧化应激和骨质量都有有益的影响。© 2022化学工业协会。
The effects of dietary fat on health are influenced by its fatty acid profile. We aimed to determine the effects of monounsaturated fatty acid (MUFA)-rich blended oils (BO) containing a balance of polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFAs) and with a low n-6/n-3 PUFA ratio on the health of rats fed normal or high-fat diets. The BO was obtained by mixing red palm oil, rice bran oil (RO), tea seed oil and flaxseed oil in appropriate proportions.BO consumption reduced the serum low-density lipoprotein cholesterol (LDL-C), non-esterified fatty acid (NEFA), insulin (INS), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1 (IL-1), high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), lipid peroxide (LPO) and oxidized LDL (ox-LDL) concentrations and the homeostasis model assessment of insulin resistance (HOMA-IR); it increased the high-density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) concentrations, and the bone mineral density (BMD) versus control oil-containing normal and high-fat diets. BO also reduced the triglyceride (TG), hs-CRP, MDA, ox-LDL and reactive oxygen species (ROS) concentrations; and increased the serum HDL-C and SOD, and BMD versus RO-containing high-fat diets. Finally, BO reduced the glucose (GLU) and INS, and HOMA-IR; it increased HDL-C, SOD, femoral weight and BMD versus RO-containing normal diets.BOs with an appropriate fatty acid profile have beneficial effects on the glucolipid metabolism, inflammation, oxidative stress and bone quality of rats when included in both normal and high-fat diets. © 2022 Society of Chemical Industry.