[The effect of heat stimulation and mechanical stress (massage) of salivary glands on the secretory parameters of salivary Hsp70. A pilot study].
[The effect of heat stimulation and mechanical stress (massage) of salivary glands on the secretory parameters of salivary Hsp70. A pilot study].
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[唾液腺热刺激和机械应力（按摩）对唾液Hsp70分泌参数的影响。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
P. Fejérdy
中科院分区：
文献类型：
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作者：
L. Féjerdy;Z. Tóth;B. Kaán;Károly Fábián Tibor;P. Csermely;P. Fejérdy
作者在之前的研究中证明了人类全唾液中存在Hsp70。在最近的研究中，作者调查了唾液腺的重复、短期加热和机械刺激是否可以特异性地改变人类整个唾液中的唾液HSP70浓度。测定唾液分泌率、唾液总蛋白浓度和全唾液淀粉酶活性等基本分泌参数。刺激时，两种刺激均显著增加分泌速率(p<；or=0.05)，静止期则降至对照水平。机械应激时第一次刺激后HSP70浓度升高，热刺激时第二次刺激后HSP70浓度升高。相反，在热刺激和机械应激的情况下，总蛋白浓度和淀粉酶活性在第一次刺激后和在第二次刺激后显著(P<；OR=0.05)增加。需要进一步的研究来评估局部加热和按摩刺激后唾液变化的持久性和临床重要性。
The presence of Hsp70 in human whole saliva was demonstrated in the authors' previous study. In the recent study the authors investigated, whether repeated, short-term heat and mechanical stimulation of the salivary glands can specifically modify the salivary Hsp70 concentration in the human whole saliva. Some other basic secretory parameters, like salivary secretion rate, total protein concentration and amylase activity of the whole saliva were also measured. Both kind of stimulation increased the secretory rate significantly (p < or = 0.05), during stimulation, but it decreased to control level in resting phases. Hsp70 concentration increased after the first stimulation in the case of mechanical stress and after the second stimulation in the case of heat stimulation. In contrast, a significant (p < or = 0.05) confluent increase of total protein concentration and amylase activity occurred after the first stimulation in the case of heat stimulation and after the second stimulation in the case of mechanical stress. Further investigations are needed to evaluate the durability and clinical importance of salivary changes following local heat and massage stimulation.