The spectrum of behaviors influenced by serotonin
The spectrum of behaviors influenced by serotonin
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DOI：
10.1016/s0006-3223(98)00139-5
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发表时间：
1998-08-01
影响因子：
10.6
通讯作者：
Lucki, I
中科院分区：
文献类型：
--
作者：
Lucki, I
5 -羟色胺对行为的多种影响为理解其作为精神疾病病因标志物的潜在作用以及调节5 -羟色胺神经传递的药物的成功药理学干预奠定了基础。关于5 -羟色胺行为功能的一般理论认为，5 -羟色胺是行为反应和运动行为调节的一般抑制剂。血清素调节行为饱腹感和宏量营养素选择的能力为肥胖和饮食失调的药物治疗提供了基础。5 -羟色胺在行为抑制中的作用可能对包括攻击性和焦虑在内的社会行为很重要。血清素在神经内分泌调节中的作用为理解血清素失调在抑郁症中的作用提供了基础。动物行为试验正被用于更好地了解抗抑郁药物行为效应背后的神经基质，并解决临床治疗中的重要问题。基础研究和临床研究之间的信息整合为未来开发更复杂的精神疾病药物治疗提供了基础。(C) 1998生物精神病学学会。
The diverse array of behavioral effects of serotonin form the basis for understanding its potential role as an etiological marker in psychiatric disorders and for the successful pharmacologic intervention of drugs regulating serotonin neurotransmission in behavior. General theories of the behavioral functions of serotonin have implicated serotonin as a general inhibitor of behavioral responding and in modulating motor behavior. The ability of serotonin to regulate behavioral satiety and macronutrient selection provides the basis for pharmacologic treatment of obesity and eating disorders. The role of serotonin in behavioral suppression may be important in social behavior involving aggression and anxiety. The role of serotonin in neuroendocrine regulation provides a basis for understanding serotonin dysregulation in depression. Animal behavior tests are being used to better understand the neural substrates underlying the behavioral effects of antidepressant drugs and to address important issues in clinical treatment. The integration of information between basic and clinical studies provides the basis for future development of more sophisticated pharmacologic treatments of psychiatric disorders. (C) 1998 Society of Biological Psychiatry.