LTP and LTD vary with layer in rodent visual cortex
LTP and LTD vary with layer in rodent visual cortex
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DOI：
10.1016/j.visres.2004.09.004
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发表时间：
2004-12-01
期刊：
影响因子：
1.8
通讯作者：
Yang, YP
中科院分区：
文献类型：
--
作者：
Daw, N;Yan, R;Yang, YP
视觉皮层的可塑性机制主要有长时程增强（LTP）、长时程抑制（LTD）和眼优势可塑性（ODP）。现在可以使用基因敲除小鼠和药理学操作来比较这三种形式的可塑性的结果。文献回顾表明，如果LTP和LTD都被完全废除，那么ODP也将被废除。在其他情况下，几乎没有相关性。我们假设这种缺乏相关性的发生是因为LTP和LTD的机制随视觉皮层的层次而变化，结果表明它们确实如此。(C)2004爱思唯尔有限公司保留所有权利。
Mechanisms of plasticity in the visual cortex have been studied with long-term potentiation (LTP), long-term depression (LTD) and ocular dominance plasticity (ODP). It is now possible to compare results from these three forms of plasticity using knockout mice, and also by pharmacological manipulations. A review of the literature shows that if both LTP and LTD are completely abolished, then ODP will also be abolished. In other situations, there is little correlation. We hypothesize that this lack of correlation occurs because the mechanisms for LTP and LTD vary with layer in the visual cortex, and results show that they do. (C) 2004 Elsevier Ltd. All rights reserved.