Physiologic response to pre-arrest bolus dilute epinephrine in the pediatric intensive care unit
Physiologic response to pre-arrest bolus dilute epinephrine in the pediatric intensive care unit
复制标题
DOI：
10.1016/j.resuscitation.2018.03.011
复制
发表时间：
2018-05-01
期刊：
影响因子：
6.5
通讯作者：
Kleinman, Monica E.
中科院分区：
文献类型：
--
作者：
Ross, Catherine E.;Asaro, Lisa A.;Kleinman, Monica E.
目的：量化小儿重症监护室骤停前大剂量稀释肾上腺素的生理效应。方法：回顾性分析2011年1月至2017年3月在我院儿科重症监护室接受静脉注射稀释肾上腺素（10 mcg/mL）的患者，年龄< 18岁，孕37周。如果剂量超过20微克/千克，或在以下情况下排除患者：限制复苏，体外膜氧合，主动胸外按压，同时给予其他血压改变干预措施或在使用肾上腺素之前记录血压正常。主要终点是肾上腺素5分钟内收缩压的变化。如果患者的收缩压变化为
Aim: To quantify the physiologic effects of pre-arrest bolus dilute epinephrine in the pediatric intensive care unit.Methods: Patients < 18 years old and >= 37 weeks gestation who received an intravenous bolus of dilute epinephrine (10 mcg/mL) in the pediatric intensive care units at our institution from January 2011 to March 2017 were retrospectively identified. Patients were excluded if doses exceeded 20 mcg/kg, or under the following circumstances: orders limiting resuscitation, extracorporeal membrane oxygenation, active chest compressions, simultaneous administration of other blood pressure-altering interventions or documented normotension prior to epinephrine. The primary outcome was change in systolic blood pressure within 5 min of epinephrine. Patients were categorized as non-responders if the change in systolic blood pressure was