A Catalyst-Free Synthesis of Phosphinic Amides Using O-Benzoylhydroxylamines.
A Catalyst-Free Synthesis of Phosphinic Amides Using O-Benzoylhydroxylamines.
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DOI：
10.1021/acs.orglett.5b03056
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发表时间：
2015-11
期刊：
影响因子：
5.2
通讯作者：
R. Zhu;Chongqing Pan;Z. Gu
中科院分区：
文献类型：
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作者：
R. Zhu;Chongqing Pan;Z. Gu
报道了一种通过仲膦氧化物(SPO)与邻苯甲酰羟胺偶联合成膦酰胺的实用方法。在K(2)CO(3)的存在下，简单地加热SPOS和O-苯甲酰羟胺的混合物，在露天系统中以中等到极好的产率得到膦酰胺。该方法为合成各种合成有价值的膦酰胺提供了一种实用的、无催化剂的方法。
A practical approach for the synthesis of phosphinic amides via the coupling of secondary phosphine oxides (SPOs) with O-benzoylhydroxylamines has been reported. Simply heating the mixture of SPOs and O-benzoylhydroxylamines in the presence of K(2)CO(3) gave the phosphinic amides in moderate to excellent yields under an open air system. This method provides a practical and catalyst-free method for the synthesis of various synthetically valuable phosphinic amides.