Selenylation Chemistry Suitable for On‐Plate Parallel and On‐DNA Library Synthesis Enabling High‐Throughput Medicinal Chemistry
Selenylation Chemistry Suitable for On‐Plate Parallel and On‐DNA Library Synthesis Enabling High‐Throughput Medicinal Chemistry
复制标题
适用于平板上平行和 DNA 文库合成的硒化化学可实现高通量药物化学
DOI：
10.1002/anie.202209209
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Wei Hou
中科院分区：
文献类型：
--
作者：
Hongtao Xu;Yan Wang;Hewei Dong;Yiyuan Zhang;Yuang Gu;Shuning Zhang;Yu Meng;Jie Li;Xiao Jie Shi;Qun Ji;Lili Liu;Peixiang Ma;Fei Ma;Guang Yang;Wei Hou
Selenium is an emerging versatile player in medicinal chemistry. In their Research Article (DOI: 10.1002/anie.202206516), Hongtao Xu, Fei Ma, Guang Yang, Wei Hou et al. introduce a bioinspired SeClick chemistry between indole and benzoselenazole, which can be used in on-plate parallel synthesis of indole-selenides libraries and selenium containing DNA-encoded libraries (SeDELs) in a modular and predictable way, thereby boosting the development of seleno-medicinal chemistry in the near future.
