NEURONAL-ACTIVITY IN THE VENTRAL TEGMENTAL AREA (VTA) DURING MOTIVATED BAR PRESS FEEDING IN THE MONKEY
NEURONAL-ACTIVITY IN THE VENTRAL TEGMENTAL AREA (VTA) DURING MOTIVATED BAR PRESS FEEDING IN THE MONKEY
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DOI：
10.1016/0006-8993(87)91021-3
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发表时间：
1987-06-16
期刊：
影响因子：
2.9
通讯作者：
SASAKI, K
中科院分区：
文献类型：
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作者：
NISHINO, H;ONO, T;SASAKI, K
记录了雌性猴子腹侧被盖区 (VTA) 58 个多巴胺能 (DA) 和 200 个非多巴胺能 (non-DA) 神经元的神经元活动，并研究了与杠铃推举喂食、感觉刺激和动机变化的相关性。根据动作电位持续时间（超过 2.5 毫秒）和对阿朴吗啡的反应来判断，DA 神经元的放电率较低（0-8 次脉冲/秒）；非 DA 神经元具有中等放电率（10-30 脉冲/秒）。三分之二的 DA 和非 DA 神经元在棒压喂食中做出反应；前者主要是强直反应，后者是阶段性反应。 15 个神经元 (5%) 对手臂向杠铃的伸展做出阶段性反应，在杠铃按压 (BP) 期间有 124 个神经元（兴奋 88，抑制 36，45%），在摄取奖励 (RW) 期间有 91 个神经元（兴奋 32，抑制 59，33%）。大多数血压反应（84/124，68%）在整个血压周期内持续紧张，与每次血压运动没有相关性。在 14 个神经元（14/124，11%）中，放电表现出特定的变化：在可口食品试验中，短暂的早期血压反应转变为强直稳定反应，并且这种变化与血压速度密切相关。在其他 20 个神经元中，血压升高、臀部抬起以及发出特定的声音要求食物时放电会增加；它在食物摄入、饮酒和腹股沟小腿刺激时减少。阿朴吗啡给药在前 5-15 分钟内会减少放电，然后随着频繁的咂嘴、恶心、不自主运动和发声而增加放电。因此，VTA 神经元主要表现出稳定的强直反应，但也表现出一些特定的相位反应。他们不仅对运动事件做出反应，而且与动机方面的变化密切相关。神经元反应在获得奖励期间是兴奋的，而在感知奖励期间或之后是抑制的。这种发射调节对于运动和/或动机行为的启动和执行可能很重要。
Neuronal activity of 58 dopaminergic (DA) and 200 non-dopaminergic (non-DA) neurons in the ventral tegmental area (VTA) of female monkeys was recorded, and correlation to bar press feeding, sensory stimulation and change in motivation was investigated. DA neurons, judged by duration of action potentials (more than 2.5 ms) and responsiveness to apomorphine, had lower firing rates (0-8 impulses/s); non-DA neurons had intermediate firing rates (10-30 impulses/s). Two-thirds of the DA and non-DA neurons responded in bar press feeding; the former with mostly tonic and the latter with phasic responses. Fifteen neurons (5%) responded phasically to arm extension toward the bar, 124 (excitation 88, inhibition 36, 45%) during bar press (BP), and 91 (excitation 32, inhibition 59, 33%) during ingestion reward (RW). Most BP responses (84/124, 68%) continued tonically througout the BP period with no correlation to each BP movement. In 14 neurons (14/124, 11%), firing showed a specific variation: transient early BP responses shifted to tonic steady ones in palatable food trials, and the shifts correlated well with BP speed. In 20 other neurons, firing increased during BP, hip lifting, and at specific vocalization to ask for food; it decreased during food ingestion, drinking and inguino-crural stimulation. Apomorphine administration decreased firing for the first 5-15 min, then increased it with frequent lip smacking, nausea, involuntary movement and vocalization. Thus VTA neurons showed mostly steady tonic responses but some specific phasic responses. They responded not only to motor events but also in close relation to changes of motivational aspects. Neuronal responses were excitation during procurement of reward and inhibition during or after perception of reward. This modulation in firing, might be important in the initiation and execution of movement and/or motivated behavior.