A model for genesis of transcription systems.
A model for genesis of transcription systems.
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DOI：
10.1080/21541264.2015.1128518
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Geiger JH
中科院分区：
文献类型：
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作者：
Burton ZF;Opron K;Wei G;Geiger JH
由RNA基因融合/连接产生的重复序列主导着古代生命，表明在进化的生物系统中构建结构复杂性的重要性。一个简单而连贯的地球生命故事是通过追踪产生α/β蛋白质的重复基序、2-双-β-桶（DPBB）型RNA聚合酶（RNAP）、一般转录因子（GTF）和启动子来讲述的。出现的一般规则是，通过重复序列的产生而产生的生物复杂性通常受到溶解度和封闭性的限制（即，以形成假二聚体或桶）。因为第一个DNA基因组是通过DNA模板依赖性RNA合成，然后通过逆转录酶进行RNA模板依赖性DNA合成来复制的，所以第一个DNA复制起点最初是2-DPBB型RNAP启动子。提出了一个简化的模型，通过重复的核心启动子元件的启动子/复制起点的进化。该模型可以解释为什么Pribnow盒在细菌转录（即，-12TATAATG-6）非常类似于TATA盒（即，-31TATAAAAG-24）在古细菌/真核生物转录中的作用。细菌中锚DNA序列的进化（即，− 35 TTGACA −30）和古细菌（BREup; BRE为TFB识别元件）启动子可能得到解释。古细菌启动子的BREDOWN元件的进化可能得到解释。
Repeating sequences generated from RNA gene fusions/ligations dominate ancient life, indicating central importance of building structural complexity in evolving biological systems. A simple and coherent story of life on earth is told from tracking repeating motifs that generate α/β proteins, 2-double-Ψ−β-barrel (DPBB) type RNA polymerases (RNAPs), general transcription factors (GTFs), and promoters. A general rule that emerges is that biological complexity that arises through generation of repeats is often bounded by solubility and closure (i.e., to form a pseudo-dimer or a barrel). Because the first DNA genomes were replicated by DNA template-dependent RNA synthesis followed by RNA template-dependent DNA synthesis via reverse transcriptase, the first DNA replication origins were initially 2-DPBB type RNAP promoters. A simplifying model for evolution of promoters/replication origins via repetition of core promoter elements is proposed. The model can explain why Pribnow boxes in bacterial transcription (i.e., −12TATAATG−6) so closely resemble TATA boxes (i.e., −31TATAAAAG−24) in archaeal/eukaryotic transcription. The evolution of anchor DNA sequences in bacterial (i.e., −35TTGACA−30) and archaeal (BREup; BRE for TFB recognition element) promoters is potentially explained. The evolution of BREdown elements of archaeal promoters is potentially explained.