Hypoglycemic brain injury: Potentiation from respiratory depression and injury aggravation from hyperglycemic treatment overshoots
Hypoglycemic brain injury: Potentiation from respiratory depression and injury aggravation from hyperglycemic treatment overshoots
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DOI：
10.1097/00004647-200001000-00012
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发表时间：
2000-01-01
影响因子：
6.3
通讯作者：
Myers, RE
中科院分区：
文献类型：
--
作者：
de Courten-Myers, GM;Xi, GH;Myers, RE
低血糖会导致脑功能障碍、脑损伤和死亡。本研究试图通过研究一种新的病因学来拓宽目前关于低血糖脑损伤机制的信息。猫对低血糖引起的脑损伤具有很高的抵抗力，这表明呼吸抑制等额外的影响可能起到了促进作用。三组猫分别接受空腹和胰岛素诱导的低血糖(HG；n=6)、正常血糖呼吸抑制(RD；n=5)和联合低血糖呼吸抑制(HG/RD；n=10)。HG动物被维持在
Hypoglycemia can cause brain dysfunction, brain injury, and death. The present study seeks to broaden current information regarding mechanisms of hypoglycemic brain injury by investigating a novel etiology. The cat's high resistance to brain injury from hypoglycemia suggested that additional influences such as respiratory depression might play a facilitating role. Three groups of cats were exposed to fasting and insulin-induced hypoglycemia (HG; n = 6), euglycemic respiratory depression (RD; n = 5), and combined hypoglycemic respiratory depression (HG/RD; n = 10). The HG animals were maintained at