Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1-positive patients
Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1-positive patients
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DOI：
10.1086/504719
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发表时间：
2006-07-01
影响因子：
6.4
通讯作者：
Lopez-Botet, Miguel
中科院分区：
文献类型：
--
作者：
Guma, Monica;Cabrera, Cecilia;Lopez-Botet, Miguel
在健康献血者中，人巨细胞病毒（HCMV）血清学阳性与携带CD 94/NKG 2C NK细胞受体（NKR）的NK细胞比例增加相关。在45例接受高效抗逆转录病毒治疗的病毒血症人类免疫缺陷病毒1型（HIV-1）阳性患者队列中研究了活化性CD 94/NKG 2C NKR和抑制性CD 94/NKG 2A NKR的表达。HIV-1阳性患者的NKG 2C（+）NK细胞比例（平均值+/- SD，25.9% +/- 23.0%）显著高于31名健康个体（平均值+/- SD，16.1% +/- 20.7%）。然而，当在多变量回归模型中考虑HCMV血清学状态时，相关性消失。这些结果支持以下结论：（HIV-1）阳性患者的NKR库变化与伴随的HCMV感染有关。
In healthy blood donors, serological positivity for human cytomegalovirus ( HCMV) is associated with an increased proportion of NK cells bearing the CD94/NKG2C NK cell receptor (NKR). The expression of the activating CD94/NKG2C NKR and of the inhibitory CD94/NKG2A NKR was studied in a cohort of 45 aviremic human immunodeficiency virus type 1 (HIV-1)-positive patients receiving highly active antiretroviral therapy. The proportions of NKG2C(+) NK cells were significantly increased in HIV-1-positive patients (mean +/- SD, 25.9% +/- 23.0%), compared with those in 31 healthy individuals viduals (mean +/- SD, 16.1% +/- 20.7%). Yet the association vanished when HCMV serological status was considered in a multivariate regression model. These results support the conclusion that changes in the NKR repertoire in (HIV-1)-positive patients are related to a concomitant HCMV infection.