Hydrogen sulfide activation in hemeproteins: the sulfheme scenario.
Hydrogen sulfide activation in hemeproteins: the sulfheme scenario.
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DOI：
10.1016/j.jinorgbio.2014.01.013
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发表时间：
2014-04
影响因子：
3.9
通讯作者：
López-Garriga J
中科院分区：
文献类型：
--
作者：
Ríos-González BB;Román-Morales EM;Pietri R;López-Garriga J
传统上被称为有毒气体的硫化氢（H2S）现在被认为是参与许多生理功能的重要生物分子。与一氧化氮（·NO）和一氧化碳（CO）一样，H2S在组织和细胞中内源性产生，并可通过作用于靶蛋白来调节生物过程。例如，H2S与人血红蛋白和肌红蛋白的氧合形式的相互作用产生与H2S降解有关的硫血红素蛋白复合物。这种硫血红素衍生物的存在也被用作内源性H2S合成和代谢的标志物。值得注意的是，人类过氧化氢酶和过氧化物酶也产生这种硫血红素产物。在这篇综述中，我们描述了这些蛋白质中的硫血红素衍生物的结构和功能方面，并假设一个普遍的机制，硫血红素蛋白质的形成。我们还评估了这种复杂的可能的生理功能，并强调仍有待评估的问题，以确定硫血红素蛋白在H2S代谢，检测和生理学中的作用。
Traditionally known as a toxic gas, hydrogen sulfide (H2S) is now recognized as an important biological molecule involved in numerous physiological functions. Like nitric oxide (•NO) and carbon monoxide (CO), H2S is produced endogenously in tissues and cells and can modulate biological processes by acting on target proteins. For example, interaction of H2S with the oxygenated form of human hemoglobin and myoglobin produces a sulfheme protein complex that has been implicated in H2S degradation. The presence of this sulfheme derivative has also been used as a marker for endogenous H2S synthesis and metabolism. Remarkably, human catalases and peroxidases also generate this sulfheme product. In this review, we describe the structural and functional aspects of the sulfheme derivative in these proteins and postulate a generalized mechanism for sulfheme protein formation. We also evaluate the possible physiological function of this complex and highlight the issues that remain to be assessed to determine the role of sulheme proteins in H2S metabolism, detection and physiology.