Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior.
Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior.
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DOI：
10.1146/annurev-physiol-021909-135843
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发表时间：
2010
影响因子：
18.2
通讯作者：
Haydon PG
中科院分区：
文献类型：
--
作者：
Halassa MM;Haydon PG
在过去的十年里，关于神经元-星形胶质细胞相互作用在控制脑功能中的作用的研究激增。我们强调最近的研究进行的三方突触，结构组成的突触前和突触后的元素和相关的星形胶质细胞的过程。星形胶质细胞通过激活代谢型受体对神经元活动和神经递质作出反应，并可释放作用于神经元的胶质递质ATP、D-丝氨酸和谷氨酸。星形胶质细胞衍生的ATP直接或通过其代谢产物腺苷调节突触传递。D-丝氨酸调节NMDA受体功能，而胶质源性谷氨酸在药物滥用戒断后复发中发挥重要作用。细胞类型特异性分子遗传学允许检查星形胶质细胞在脑功能中的功能的新水平，并揭示了这些神经胶质细胞在控制睡眠和睡眠剥夺后的认知障碍中由腺苷积累介导的重要作用。
The past decade has seen an explosion of research on roles of neuron-astrocyte interactions in the control of brain function. We highlight recent studies performed on the tripartite synapse, the structure consisting of pre- and postsynaptic elements of the synapse and an associated astrocytic process. Astrocytes respond to neuronal activity and neuro-transmitters, through the activation of metabotropic receptors, and can release the gliotransmitters ATP, D-serine, and glutamate, which act on neurons. Astrocyte-derived ATP modulates synaptic transmission, either directly or through its metabolic product adenosine. D-serine modulates NMDA receptor function, whereas glia-derived glutamate can play important roles in relapse following withdrawal from drugs of abuse. Cell type–specific molecular genetics has allowed a new level of examination of the function of astrocytes in brain function and has revealed an important role of these glial cells that is mediated by adenosine accumulation in the control of sleep and in cognitive impairments that follow sleep deprivation.
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影响因子：
5.3
作者：
Djukic, Biljana;Casper, Kristen B.;McCarthy, Ken D.
通讯作者：
McCarthy, Ken D.
影响因子：
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25
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影响因子：
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作者：
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