Subcortical hyperintensities on brain magnetic resonance imaging: a comparison of normal and bipolar subjects.
Subcortical hyperintensities on brain magnetic resonance imaging: a comparison of normal and bipolar subjects.
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脑磁共振成像的皮层下高信号：正常和双相情感障碍受试者的比较。
DOI：
10.1176/jnp.3.1.18
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Boyko,O
中科院分区：
文献类型：
--
作者：
Figiel,GS;Krishnan,KR;Rao,VP;Doraiswamy,M;EllinwoodJr,EH;Nemeroff,CB;Evans,D;Boyko,O
据报道，双相情感障碍经常出现在一些皮质下疾病中。这表明皮质下结构可能参与了某些患者双相情感障碍的病因学。随着脑磁共振成像(MRI)的出现，现在可以在体内可视化皮质下的白质和灰质，从而能够检查这些结构。作者报告说，双相情感障碍患者深部白质损害的发生率(44%)高于年龄匹配的对照组(6%)。将讨论这些损伤的神经解剖学和临床相关性，以及它们潜在的病理生理学意义。
Bipolar disorder has been reported to occur frequently in a number of subcortical diseases. This suggests that subcortical structures may be involved in the etiology of bipolar disorder in some patients. With the advent of brain magnetic resonance imaging (MRI), in vivo visualization of the subcortical white and gray matter is now possible, allowing the examination of these structures. The authors report a higher occurrence of deep white matter lesions in bipolar patients (44%) compared with age-matched controls (6%). The neuroanatomic and clinical correlates of these lesions will be discussed, along with their potential pathophysiologic significance.