Alzheimer's disease frequency peaks in the tenth decade and is lower afterwards
Alzheimer's disease frequency peaks in the tenth decade and is lower afterwards
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DOI：
10.1186/s40478-019-0752-0
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发表时间：
2019-07-03
影响因子：
7.1
通讯作者：
Bennett, David A.
中科院分区：
文献类型：
--
作者：
Farfel, Jose M.;Yu, Lei;Bennett, David A.
年龄是阿尔茨海默氏痴呆症最强大的风险因素，然而，关于年龄与阿尔茨海默氏病（AD）和其他常见神经病理学的关系的数据很少，这些神经病理学导致阿尔茨海默氏痴呆症。我们使用来自两个以社区为基础的临床病理队列的数据来研究年龄与AD和其他常见病理的关联。参与者是来自宗教秩序研究或拉什记忆和衰老项目的1420名尸检人员，他们接受了阿尔茨海默氏痴呆症，轻度认知障碍（MCI）和认知水平的年度临床诊断评估。感兴趣的神经病理学特征是根据改良的NIA-Reagan标准的病理性AD、AD病理学的三种定量测量（总体AD病理学评分、β-淀粉样蛋白负荷和PHFtau缠结密度）、宏观和微观梗死、新皮质Lewy小体、TDP-43和海马硬化。半参数广义加性模型研究了年龄与临床和病理结果之间的非线性关系。死亡时阿尔茨海默氏痴呆症的概率随着年龄的增加而增加，因此年龄每增加一岁，阿尔茨海默氏痴呆症的对数几率就增加0.067，相应的比值比为1.070（p
Age is the most robust risk factor for Alzheimer's dementia, however there is little data on the relation of age to Alzheimer's disease (AD) and other common neuropathologies that contribute to Alzheimer's dementia. We use data from two community-based, clinical-pathologic cohorts to examine the association of age with AD and other common pathologies. Participants were 1420 autopsied individuals from the Religious Orders Study or Rush Memory and Aging Project who underwent annual clinical evaluations for diagnosis of Alzheimer's dementia, mild cognitive impairment (MCI), and level of cognition. The neuropathologic traits of interest were pathologic AD according to modified NIA-Reagan criteria, three quantitative measures of AD pathology (global AD pathology score, beta-amyloid load and PHFtau tangle density), macro- and micro-scopic infarcts, neocortical Lewy bodies, TDP-43 and hippocampal sclerosis. Semiparametric generalized additive models examined the nonlinear relationship between age and the clinical and pathological outcomes. The probability of Alzheimer's dementia at death increased with age such that for every additional year of age, the log odds of Alzheimer's dementia was 0.067 higher, corresponding to an odds ratio of 1.070 (p