Tuning of the vinyl groups' spacing at surface of modified silica in preparation of high density imprinted layer-coated silica nanoparticles: A dispersive solid-phase extraction materials for chlorpyrifos
Tuning of the vinyl groups' spacing at surface of modified silica in preparation of high density imprinted layer-coated silica nanoparticles: A dispersive solid-phase extraction materials for chlorpyrifos
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DOI：
10.1016/j.talanta.2010.01.044
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发表时间：
2010-05-15
期刊：
影响因子：
6.1
通讯作者：
Zhang, Zhongping
中科院分区：
文献类型：
--
作者：
Lu, Qing;Chen, Xuemei;Zhang, Zhongping
本文报道了一种高密度印迹层包覆二氧化硅纳米粒子的制备方法，用于复杂基质中毒死蜱的选择性识别和快速富集。利用分子印迹聚合物（MIPs）表面化学固定的乙烯基，在模板CP存在下，通过甲基丙烯酸（MAA）和乙二醇二甲基丙烯酸酯（EGDMA）的接枝共聚反应，成功地将MIPs包覆在改性二氧化硅表面。研究表明，通过改变化学修饰条件、调节印迹壳层厚度和有效印迹位点密度，可以控制硅胶表面末端乙烯基的间距。通过溶剂萃取除去模板后，在聚合物涂层中产生CP的识别位点。CP分子印迹纳米粒子对CP具有较高的识别选择性和结合亲和力。当CP-印迹纳米粒子作为分散固相萃取（dSPE）材料时，一步萃取可获得76.1-93.5%的高回收率。本文报道的这些结果提供了可能性，从复杂的矩阵分离和富集CP的分子印迹修饰在普通的二氧化硅纳米粒子的表面。皇冠版权所有（C）2010由爱思唯尔出版。All rights reserved.
This paper reports the preparation of high density imprinted layer-coated silica nanoparticles toward selective recognition and fast enrichment of chlorpyrifos (CP) from complicated matrices. The molecularly imprinted polymers (MIPs) were successfully coated at the surface of modified silica through using the chemical immovable vinyl groups at the nanoparticles' surface, followed by the graft copolymerization of methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) in the presence of templates CP. It has been demonstrated that the space of end vinyl groups at the surface of silica can be controlled by changing the condition of chemical modification, regulating the thickness of imprinted shells and the density of efficient imprinted sites. After removal of templates by solvent extraction, the recognition sites of CP were created in the polymer coating layer. The CP-imprinted nanoparticles exhibited high recognition selectivity and binding affinity to CP analyte. When the CP-imprinted nanoparticles were used as dispersive solid-phase extraction (dSPE) materials, the high recovery yields of 76.1-93.5% from various spiked samples with only 1 mu g/mL analyte were achieved by one-step extraction. These results reported herein provide the possibility for the separation and enrichment of CP from complicated matrices by the molecular imprinting modification at the surface of common silica nanoparticles. Crown Copyright (C) 2010 Published by Elsevier By. All rights reserved.