Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease:: Verbal versus design fluency
Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease:: Verbal versus design fluency
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DOI：
10.1017/s1355617705051015
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发表时间：
2005-11-01
影响因子：
2.6
通讯作者：
Bondi, MW
中科院分区：
文献类型：
--
作者：
Houston, WS;Delis, DC;Bondi, MW
最近的研究报道了阿尔茨海默病（AD）患者和处于AD临床前阶段的载脂蛋白E β 4（APOE β 4）基因型个体的认知不对称性。这种认知不对称的频率增加，通常被定义为言语和空间能力之间的显著差异（在任一方向上），尽管在传统的集中趋势测量上没有差异（即，平均测试分数）。我们前瞻性地研究了APOE基因型和两项特定于智力的执行功能任务之间的关系：在52名功能正常的老年人参与者中进行Delis-Kaplan执行功能系统（D-KEFS）的言语流畅性和设计流畅性测试，这些参与者根据APOE β 4等位基因的存在（n = 24）或不存在（n = 28）进行分组。非痴呆老年人与APOE β 4等位基因表现出更大的频率的认知不对称配置文件的新切换条件下的语言和设计流畅性措施比APOE非β 4个人。本研究进一步支持评估认知不对称性用于检测AD风险个体的细微认知差异的效用，并建议双任务执行功能测试（即，流畅性加转换）可以作为AD的有用的临床前市场。
Recent studies have reported cognitive asymmetries in patients with Alzheimer's disease (AD) and in individuals with apolipoprotein E epsilon 4 (APOE epsilon 4) genotype who are in the preclinical phase of AD. This increased frequency of cognitive asymmetry, typically defined as a significant discrepancy (in either direction) between verbal and spatial abilities, often occurs despite an absence of differences on traditional measures of central tendency (i.e., mean test scores). We prospectively studied the relationship between APOE genotype and two rnodality-specific executive-function tasks: The Verbal Fluency and Design Fluency tests of the Delis-Kaplan Executive Function System (D-KEFS) in 52 normal functioning older adult participants who were grouped according to the presence (n = 24) or absence (n = 28) of the APOE epsilon 4 allele. Nondemented older adults with the APOE epsilon 4 allele demonstrated a greater frequency of cognitive asymmetric profile on the new switching conditions of the Verbal and Design Fluency measures than the APOE non-epsilon 4 individuals. This Study further Supports the utility of assessing cognitive asymmetry for the detection of subtle cognitive differences in individuals at-risk for AD, and suggests that dual-task executive function tests (i.e., fluency plus switching) may serve as a useful preclinical market of AD.