Firing rate modulation: A simple statistical view of memory trace reactivation
Firing rate modulation: A simple statistical view of memory trace reactivation
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DOI：
10.1016/j.neunet.2005.08.011
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发表时间：
2005-11-01
期刊：
影响因子：
7.8
通讯作者：
Harris, KD
中科院分区：
文献类型：
--
作者：
Battaglia, FP;Sutherland, GR;Harris, KD
在睡眠期间海马集合体中的记忆痕迹再激活被认为是巩固新记忆的协调机制。在这里，我们提出了一个简单的统计方案，允许分析的放电率调制的再激活，一个定义明确的零假设。这种方法允许可靠的检测合奏重新激活在三个实验设置。放电率调制的再激活反映了几个属性的常用研究的再激活措施：它是在海马尖波较强，并在10-20分钟的时间内衰减。此外，在某些条件下，放电率再激活协变与再激活的细胞对交叉相关性，这两种现象反映了类似的过程。我们提出了一个吸引子网络模型，与预先布线的吸引子，在经验选择和素数的一些吸引子。启动通过经验依赖性突触可塑性或神经元兴奋性的变化发生。启动吸引子更有可能在接下来的睡眠中激活，诱导速率和交叉相关性的重新激活。(c)2005年由Elsevier Ltd.出版
Memory trace reactivation in hippocampal ensembles during sleep has been suggested as a coordinating mechanism for consolidation of new memories. Here we propose a simple statistical scheme allowing analysis of the reactivation of firing rate modulations, with a well-defined null hypothesis. This method allowed reliable detection of ensemble reactivation across three experimental settings. Reactivation of firing rate modulations mirrors several properties of commonly studied reactivation measures: it is stronger during hippocampal sharp waves, and decays over a period of 10-20 min.Moreover, in some conditions, firing rate reactivation covaries with reactivation of cell pair cross-correlations, suggesting the two phenomena reflect similar processes. We propose an attractor network model, with pre-wired attractors, in which experience selects and primes some attractors. Priming occurs by either experience dependent synaptic plasticity or changes in neuronal excitability. Primed attractors are more likely to activate in the following sleep, inducing reactivation of both rates and cross-correlations. (c) 2005 Published by Elsevier Ltd.