Conserved function for embryonic nodal cilia
Conserved function for embryonic nodal cilia
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DOI：
10.1038/418037a
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发表时间：
2002-07-04
期刊：
影响因子：
64.8
通讯作者：
Brueckner, M
中科院分区：
文献类型：
--
作者：
Essner, JJ;Vogan, KJ;Brueckner, M
左右利手是如何起源于发育中的脊椎动物胚胎的身体平面的，这是一个备受争议的话题。在小鼠中，左右偏向被认为是由定向细胞外流动（结流）引起的，该细胞外流动是由胚胎结腹侧表面上的动力蛋白依赖性单眼旋转产生的。在这里，我们表明，存在的节点monocilia和动力蛋白基因的表达，涉及纤毛功能是保守的范围广泛的脊椎动物类，表明一个类似的纤毛机制可能是建立在所有脊椎动物的利手。
How left–right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate,. In mice, a left–right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node,. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.