Long-chain n-3 polyunsaturated fatty acids decrease feelings of anger in substance abusers
Long-chain n-3 polyunsaturated fatty acids decrease feelings of anger in substance abusers
复制标题
DOI：
10.1016/j.psychres.2007.01.004
复制
发表时间：
2008-01-15
影响因子：
11.3
通讯作者：
Branchey, Marc
中科院分区：
文献类型：
--
作者：
Buydens-Branchey, Laure;Branchey, Marc
研究表明，低水平的n-3多不饱和脂肪酸（PUFA）在某些精神疾病的病理生理学中发挥作用。鉴于高频率和高严重性攻击行为与物质使用障碍之间存在强相关性，以及我们观察到物质滥用者具有不良饮食习惯，探索了施用n-3 PUFA补充剂将降低其愤怒水平的可能性。在24名患者中获得了攻击性行为和法律问题的终身史。13名患者每天接受含有3 g n-3 PUFA（EPA+DHA）的胶囊。11例患者接受安慰剂胶囊。该试验是双盲、随机的，持续3个月。在基线和此后每个月进行愤怒量表测量。PUFA组的6名患者和安慰剂组的8名患者在治疗停止后再随访3个月。每组中有4名患者有攻击行为史。这8名患者的基线鱼和n-3 PUFA摄入量显著低于非侵袭性患者。当给药3个月时，n-3 PUFA在降低愤怒评分方面优于安慰剂上级。在治疗停止后3个月，评分保持下降。这些数据为新出现的证据提供了进一步的支持，这些证据表明，补充长链n-3 PUFA可能有助于治疗一些具有攻击性倾向的个体。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
It has been suggested that low levels of n-3 polyunsaturated fatty acids (PUFAs) play a role in the pathophysiology of some psychiatric disorders. In light of the existence of strong associations between high-frequency and high-severity aggressive behaviors and substance use disorders and of our observation that substance abusers have poor dietary habits, the possibility that the administration of supplements of n-3 PUFAs would decrease their anger levels was explored. A lifelong history of aggressive behaviors and problems with the law was obtained in 24 patients. Thirteen patients received on a daily basis capsules containing 3 g of n-3 PUFAs (EPA+DHA). Eleven patients received placebo capsules. The trial was double-blind, randomized, and lasted 3 months. An anger scale was administered at baseline and every month thereafter. Six PUFA group patients and eight placebo group patients were followed for an additional 3 months after treatment discontinuation. Four patients in each group had a history of assaultive behavior. The baseline fish and n-3 PUFA intakes of these eight patients were significantly lower than those of the non-aggressive patients. When given for 3 months, n-3 PUFAs were superior to placebo in diminishing anger scores. Scores remained decreased for 3 months following treatment discontinuation. These data provide further support for emerging evidence indicating that supplementation with long-chain n-3 PUFAs could be beneficial in the treatment of some individuals with aggressive tendencies. (c) 2007 Elsevier Ireland Ltd. All rights reserved.