A crossover, add-on trial of talampanel in patients with refractory partial seizures
A crossover, add-on trial of talampanel in patients with refractory partial seizures
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DOI：
10.1212/wnl.58.11.1680
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发表时间：
2002-06-11
期刊：
影响因子：
9.9
通讯作者：
Arroyo, S
中科院分区：
文献类型：
--
作者：
Chappell, AS;Sander, JW;Arroyo, S
作者报告了一项在49例难治性部分性癫痫发作患者中进行的他仑帕奈双盲、安慰剂对照、交叉研究。基于患者合并使用抗癫痫药物的差异，研究了三种剂量的他仑帕奈。Talampanel显示出降低癫痫发作频率的疗效（p = 0.001），中位癫痫发作减少21%。与安慰剂组相比，80%的患者在他仑帕奈组癫痫发作较少。头晕（52%）和共济失调（26%）是仅有的显著不良事件。
The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) with a median seizure reduction of 21%. Eighty percent of patients had fewer seizures on talampanel than on placebo. Dizziness (52%) and ataxia (26%) were the only significant adverse events.