Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene
Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene
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DOI：
10.1016/s0966-842x(97)01129-3
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发表时间：
1997-10-01
影响因子：
15.9
通讯作者：
Flemington, E
中科院分区：
文献类型：
--
作者：
Speck, SH;Chatila, T;Flemington, E
eb病毒（EBV）感染的B细胞从潜伏感染到病毒复制的转换是由病毒BZLF1基因的表达启动的。最近的研究已经确定了参与调节病毒程序中这种开关的关键细胞转录因子及其响应的信号转导途径。了解这种转换可能有助于制定干预EBV感染的策略。
The switch from latent infection to virus replication in Epstein-Barr virus (EBV)-infected B cells is initiated by expression of the viral BZLF1 gene. Recent studies have identified the key cellular transcription factors involved in regulating this switch in viral programs and the signal transduction pathways to which they respond. Understanding this switch may facilitate development of strategies to interfere with EBV infection.