Human placental form of glutathione S-transferase (GST-pi) as a new immunohistochemical marker for human colonic carcinoma.
Human placental form of glutathione S-transferase (GST-pi) as a new immunohistochemical marker for human colonic carcinoma.
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人胎盘形式的谷胱甘肽 S-转移酶 (GST-pi) 作为人结肠癌的新免疫组织化学标记物。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
Kiyomi Sato
中科院分区：
文献类型：
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作者：
C. Kodate;A. Fukushi;T. Narita;H. Kudo;Yasushi Soma;Kiyomi Sato
用抗人胎盘型谷胱甘肽S转移酶(GST-pi)的抗体，用过氧化物酶-抗-过氧化物酶标法检测了人结肠癌和结肠腺瘤中的胎盘型谷胱甘肽-pI。在包括分化腺癌和未分化癌在内的60例癌中，GST-pi染色阳性率为88%，23例腺瘤中阳性率为47%。在正常结肠粘膜中，GST-pi在吸收细胞的基底部或少量粘蛋白的细胞质中未检测到或仅有微弱的染色。提示GST-pI可能是结肠癌和某些腺瘤免疫组织化学检测的新标记物。
Human placental form of glutathione S-transferase (GST-pi) was detected in human colonic carcinomas and adenomas by peroxidase anti-peroxidase method using antibody raised against GST-pi. Of 60 carcinomas, including differentiated adenocarcinomas and undifferentiated carcinomas, 88% were positive for GST-pi staining, and 47% of 23 adenomas were also positive. In the normal colonic mucosa, GST-pi was not detectable or was only weakly stained in the basal parts of the absorptive cells or in the cytoplasm of the cells containing little mucin. These results indicate that GST-pi is a possible new marker for immunohistochemical detection of human colonic carcinoma and some adenomas.