A novel method for evaluating human carotid artery elasticity: Possible detection of early stage atherosclerosis in subjects with type 2 diabetes
A novel method for evaluating human carotid artery elasticity: Possible detection of early stage atherosclerosis in subjects with type 2 diabetes
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DOI：
10.1016/j.atherosclerosis.2006.11.020
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发表时间：
2008-01-01
期刊：
影响因子：
5.3
通讯作者：
Oka, Yoshitomo
中科院分区：
文献类型：
--
作者：
Okimoto, Hisashi;Ishigaki, Yasushi;Oka, Yoshitomo
我们最近开发了一种新的方法来评估动脉壁的弹性，分阶段跟踪方法。在此，我们评估了242例2型糖尿病患者的颈动脉粥样硬化。在多元回归分析中，年龄、收缩压和高脂血症与颈动脉弹性值独立相关。我们还测量了这些受试者目前建立的动脉粥样硬化、颈动脉IMT和baPWV值。颈动脉弹性与最大IMT（r = 0.291，p < 0.01）、斑块积分（r = 0.220，p < 0.01）和baPWV（r = 0.345，p < 0.01）相关。弹性、最大IMT和斑块评分均与动脉粥样硬化的危险因素（即高血压、高脂血症和吸烟以及糖尿病）的数量相关，这与这些值反映动脉粥样硬化的观点一致。然而，重要的是，在IMT < 1.1 mm的受试者中，根据IMT标准被归类为没有动脉粥样硬化，只有颈动脉弹性与危险因素的数量相关（p < 0.05）。这些结果表明：（1）测量的颈动脉弹性值反映动脉粥样硬化和（2）我们的新方法有可能在早期检测动脉粥样硬化。(C)2006爱思唯尔爱尔兰有限公司保留所有权利。
We recently developed a novel method for evaluating the elasticity of arterial walls, the phased tracking method. Herein, we evaluated atherosclerosis of the carotid artery with this method in 242 individuals with type 2 diabetes. In multiple regression analysis of subject status, age, systolic blood pressure and hyperlipidemia were found to be independently associated with carotid artery elasticity values. We also measured currently established values for atherosclerosis, carotid artery IMT and baPWV, in these subjects. Carotid artery elasticity correlated with max IMT (r = 0.291, p < 0.01), plaque score (PS) (r = 0.220, p < 0.01) and baPWV (r = 0.345, p < 0.01). Elasticity, max IMT and plaque score, all correlated with the number of risk factors for atherosclerosis, i.e. hypertension, hyperlipidemia and smoking, in addition to diabetes, consistent with the view that these values reflect atherosclerosis. Importantly, however, in subjects with IMT < 1.1 mm, who are classified as not having atherosclerosis as defined by IMT criteria, only carotid artery elasticity correlated with the number of risk factors (p < 0.05). These results suggest that (1) the measured carotid artery elasticity values reflect atherosclerosis and (2) our novel method has potential for detecting atherosclerosis in its early stage. (C) 2006 Elsevier Ireland Ltd. All rights reserved.