Association between+1059G/C CRP Polymorphism and Acute Myocardial Infarction in a Cohort of Patients from Sicily A Pilot Study
Association between+1059G/C CRP Polymorphism and Acute Myocardial Infarction in a Cohort of Patients from Sicily A Pilot Study
复制标题
DOI：
10.1196/annals.1354.036
复制
发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Candore, Giuseppina
中科院分区：
文献类型：
--
作者：
Balistreri, Carmela Rita;Vasto, Sonya;Candore, Giuseppina
炎症在动脉粥样硬化的所有阶段都起作用，急性期反应物C-反应蛋白（CRP）的产生增加可预测未来的心血管事件。此外，CRP被认为在动脉粥样硬化的发病机制中起作用;因此，CRP多态性可能与急性心肌梗死（AMI）有关。我们分析了来自西西里的AMI男性患者和健康的年龄相关男性对照的+1059 G/ C CRP单核苷酸多态性（SNP）。与对照组相比，患者组+1059 C SNP的频率显著升高（P=0.0008; OR 3.86）。C+健康受试者的CRP血清水平显著高于C-受试者（P=0.0075）。在同质白种人人群中进行的本先导性病例对照研究的结果表明，+1059 C CRP基因SNP与AMI相关。在任何情况下，本研究的结果都应该增加越来越多的证据，证明促炎基因型在不成功的衰老中的作用，决定了对免疫炎症性疾病如冠心病的易感性。
Inflammation plays a role in all the phases of atherosclerosis, and increased production of the acute-phase reactant, C-reactive protein (CRP), predicts future cardiovascular events. Furthermore, CRP has been claimed to play a role in the pathogenesis of atherosclerosis; therefore, CRP polymorphisms might be associated with acute myocardial infarction (AMI). We have analyzed male patients affected by AMI and healthy age-related male controls from Sicily for + 1059G/ C CRP single-nucleotide polymorphism (SNP). There was a significantly higher frequency of + 1059C SNP (P=0.0008; OR3.86) in patients compared to controls. CRP serum levels were significantly higher in C+ healthy subjects rather than in C-subjects (P=0.0075). The results of the present pilot case-control study performed in a homogeneous caucasoid population suggest that + 1059C CRP gene SNP is associated with AMI. In any case, the results of the present study should add to the growing body of evidence on the role of pro-inflammatory genotypes in unsuccessful aging, determining susceptibility to immune-inflammatory diseases such as coronary heart disease.