Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior
Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior
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DOI：
10.1016/j.neuron.2005.08.007
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发表时间：
2005-09-15
期刊：
影响因子：
16.2
通讯作者：
Everitt, BJ
中科院分区：
文献类型：
--
作者：
Lee, JLC;Di Ciano, P;Everitt, BJ
众所周知，将环境刺激与滥用药物的影响联系起来的适应不良记忆是药物成瘾习惯复发和持续的主要原因。然而，记忆在获得和巩固后可能会因损害其重新巩固而受到干扰。在这里，我们表明，在条件刺激（CS）-可卡因关联的良好学习记忆重新激活之前，将 Zif268 反义寡脱氧核苷酸输注到基底外侧杏仁核中，消除了药物相关刺激的获得性条件强化特性，从而消除了它对学习新的可卡因寻求反应的影响。此外，我们发现 CS 恐惧记忆的重新整合也需要杏仁核中的 Zif268。这些结果表明，食欲性 CS 药物记忆以类似于厌恶记忆的方式进行重新巩固，并且这种依赖杏仁核的重新巩固可以被破坏，以减少药物线索对药物寻求的影响。
Maladaptive memories that associate environmental stimuli with the effects of drugs of abuse are known to be a major cause of relapse to, and persistence of, a drug addictive habit. However, memories may be disrupted after their acquisition and consolidation by impairing their reconsolidation. Here, we show that infusion of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala, prior to the reactivation of a well-learned memory for a conditioned stimulus (CS)-cocaine association, abolishes the acquired conditioned reinforcing properties of the drug-associated stimulus and thus its impact on the learning of a new cocaine-seeking response. Furthermore, we show that reconsoliclation of CS-fear memories also requires Zif268 in the amygdala. These results demonstrate that appetitive CS-drug memories undergo reconsoliclation in a manner similar to aversive memories and that this amygdala-dependent reconsolidation can be disrupted to reduce the impact of drug cues on drug seeking.