NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina
NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina
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DOI：
10.1016/j.peptides.2009.10.014
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发表时间：
2010-01-01
期刊：
影响因子：
3
通讯作者：
Tooyama, Ikuo
中科院分区：
文献类型：
--
作者：
Abdelalim, Essam Mohamed;Tooyama, Ikuo
已知利钠肽受体C（NPR-C）以相似的亲和力结合所有利钠肽。考虑到它们的生物学作用，有趣的是利钠肽及其活化的鸟苷酸环化酶（NPR-A和NPR-B）在视网膜无长突细胞中表达。本研究的目的是研究存在的NPR-C在大鼠视网膜和它的关系，胆碱能和多巴胺能无长突细胞，使用免疫荧光技术。NPR-C免疫反应在视网膜的几个层中被发现，包括神经节细胞层（GCL）、内核层（INL）、外丛状层（OPL）和光感受器内段（IS）。免疫荧光双标记显示NPR-C与酪氨酸羟化酶（多巴胺能细胞的标志物）和胆碱乙酰转移酶（ChAT）（胆碱能细胞的标志物）共定位。这些数据表明，利钠肽可能通过与NPR-C相互作用在维持视网膜功能中发挥作用。(C)2009 Elsevier Inc.版权所有
Natriuretic peptide receptor C (NPR-C) is known to bind all natriuretic peptides with similar affinity. Given their biological role it is interesting that natriuretic peptides and their activated guanylate cyclases (NPR-A and NPR-B) are expressed in retinal amacrine cells. The purpose of this study is to examine the presence of NPR-C in the rat retina and its relationship to cholinergic and dopaminergic amacrine cells using immunofluorescence techniques. NPR-C immunoreactivity was found in several layers of the retina including the ganglion cell layer (GCL), inner nuclear layer (INL), outer plexiform layer (OPL), and inner segments of photoreceptors (IS). Immunofluorescence double-labeling showed the co-localization of NPR-C with tyrosine hydroxylase, a marker of dopaminergic cells, and with choline acetyltransferase (ChAT), a marker of cholinergic cells. These data suggest that natriuretic peptides may play a role in maintaining the retinal functions via interaction with NPR-C. (C) 2009 Elsevier Inc. All rights reserved