Effect of furosemide on pulmonary blood flow distribution in resting and exercising horses.
Effect of furosemide on pulmonary blood flow distribution in resting and exercising horses.
复制标题
呋塞米对马休息和运动时肺血流分布的影响。
DOI：
10.1152/jappl.1999.86.6.2034
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Hlastala,MP
中科院分区：
文献类型：
--
作者：
Erickson,HH;Bernard,SL;Glenny,RW;Fedde,MR;Polissar,NL;Basaraba,RJ;Walther,SM;Gaughan,EM;McMurphy,R;Hlastala,MP
我们用15 μm荧光标记微球测定了5匹纯种马静注呋塞米（0.5mg/kg iv）前和后4 h静息和运动时肺血流量（PBF）的空间分布。这项研究的主要发现是PBF再分布发生从休息到运动，无论有和没有速尿。然而，有较少的血流量在运动期间postfurosemide相比prefurosemide的肺背侧部分。呋塞米确实通过增加肺腹侧区域的血流来改变静息灌注分布;然而，运动会减弱血流的增加。其他发现包括：1）呋塞米给药后与给药前相比，静息和运动时气体交换和心输出量无变化，2）呋塞米给药后肺动脉压降低，3）运动时PBF与肺垂直高度关系的斜率增加，无论是否使用呋塞米，以及4）呋塞米给药后静息时肺背侧血流量减少。肺内的肺灌注变异性可以是肺血管的解剖结构的函数，其导致流量分布的主要固定的空间模式。
We determined the spatial distribution of pulmonary blood flow (PBF) with 15-μm fluorescent-labeled microspheres during rest and exercise in five Thoroughbred horses before and 4 h after furosemide administration (0.5 mg/kg iv). The primary finding of this study was that PBF redistribution occurred from rest to exercise, both with and without furosemide. However, there was less blood flow to the dorsal portion of the lung during exercise postfurosemide compared with prefurosemide. Furosemide did alter the resting perfusion distribution by increasing the flow to the ventral regions of the lung; however, that increase in flow was abated with exercise. Other findings included1) unchanged gas exchange and cardiac output during rest and exercise after vs. before furosemide,2) a decrease in pulmonary arterial pressure after furosemide,3) an increase in the slope of the relationship of PBF vs. vertical height up the lung during exercise, both with and without furosemide, and4) a decrease in blood flow to the dorsal region of the lung at rest after furosemide. Pulmonary perfusion variability within the lung may be a function of the anatomy of the pulmonary vessels that results in a predominantly fixed spatial pattern of flow distribution.