Genetic analysis of wild-type poliovirus importation into the Netherlands (1979-1995)
Genetic analysis of wild-type poliovirus importation into the Netherlands (1979-1995)
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DOI：
10.1086/514081
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发表时间：
1997-09-01
影响因子：
6.4
通讯作者：
vanderAvoort, HGAM
中科院分区：
文献类型：
--
作者：
Mulders, MN;Reimerink, JHJ;vanderAvoort, HGAM
在流行期（1978年和1992-1993年）之外，荷兰曾多次从国外感染的病人、亚临床感染者和河水中分离出野生脊髓灰质炎病毒。序列比较揭示了不同的输入来源：地中海、印度和印度尼西亚。所观察到的广泛遗传变异表明是重复输入，而不是本地传播。直到1983年，在临床和环境标本中发现了与1978年流行的1型毒株相同或密切相关的分离株，可能是由于从土耳其反复输入所致。与1992-1993年流行的3型病毒有关的病毒在流行之前已经分离了6次。特别重要的是两种有记录的原始野生脊髓灰质炎病毒分离株，与用于生产灭活疫苗的病毒难以区分。这些数据强调了未接种疫苗的宗教人群暴露于野生脊髓灰质炎病毒的持续风险。
Wild polioviruses were isolated a number of times in The Netherlands outside the epidemic periods (1978 and 1992-1993) from patients infected abroad, from subclinically infected persons, and from river water. Sequence comparisons revealed discrete sources of importation: the Mediterranean, India, and Indonesia. The observed wide genetic variation is indicative of repeated importation and not of indigenous circulation. Isolates identical or closely related to the epidemic type 1 strain of 1978 were found in clinical and environmental specimens until 1983, probably due to repeated importation from Turkey. Viruses related to the 1992-1993 epidemic type 3 virus had already been isolated six times before the epidemic. Of particular importance are two documented isolations of prototype wild poliovirus indistinguishable from that used to produce the inactivated vaccine. These data underscore the continued risk to the unvaccinated religious population of exposure to wild poliovirus.